RBP1 blocking peptide Reference: GTX89561-PEP This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 28]
PODS® Human IGF-1 Reference: PPH34-250 The product contains the polyhedrin protein co-crystalized with Human IGF-1. Insulin-like Growth Factor 1 (IGF-1) is a growth factor that is produced by the liver. IGF-1 production is stimulated by Growth Hormone. IGF-1 binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-1 is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.
Bid blocking peptide Reference: GTX89562-PEP This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 28]
PODS® Human IGF-1 Reference: PPH34-1000 The product contains the polyhedrin protein co-crystalized with Human IGF-1. Insulin-like Growth Factor 1 (IGF-1) is a growth factor that is produced by the liver. IGF-1 production is stimulated by Growth Hormone. IGF-1 binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-1 is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.
ERK1 blocking peptide Reference: GTX89563-PEP The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 28]
PODS® Human IGF-1 L3R Reference: PPH328-50 The product contains the polyhedrin protein co-crystalized with Human IGF-1 L3R. Insulin-like Growth Factor 1 (IGF-1) is a growth factor that is produced by the liver. IGF-1 production is stimulated by Growth Hormone. IGF-1 binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-1 is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.
DPP10 blocking peptide Reference: GTX89564-PEP This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 28]
PODS® Human IGF-1 L3R Reference: PPH328-250 The product contains the polyhedrin protein co-crystalized with Human IGF-1 L3R. Insulin-like Growth Factor 1 (IGF-1) is a growth factor that is produced by the liver. IGF-1 production is stimulated by Growth Hormone. IGF-1 binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-1 is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.
CHMP5 blocking peptide Reference: GTX89565-PEP CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 1641), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 26 [PubMed 1673941]).[supplied by OMIM, Mar 28]
PODS® Human IGF-1 L3R Reference: PPH328-1000 The product contains the polyhedrin protein co-crystalized with Human IGF-1 L3R. Insulin-like Growth Factor 1 (IGF-1) is a growth factor that is produced by the liver. IGF-1 production is stimulated by Growth Hormone. IGF-1 binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-1 is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.
DYX1C1 (Isoform a) blocking peptide Reference: GTX89566-PEP This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp7 and Hsp9. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 211]
PODS® Human IL-2 Reference: PPH12-50 The product contains the polyhedrin protein co-crystalized with Human IL-2. Interleukin-2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, Natural Killer cells, monocytes, and macrophages.