HEXIM1 blocking peptide Reference: GTX89214-PEP Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 28]
Recombinant Mouse RELM-γ (Animal-Free) Reference: GFM89AF-1000 Resistin-like molecule-γ (RELM-γ) is a member of the RELM-family of secreted proteins containing C-terminal cysteines. The RELM-family consists of resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). RELM-γ is secreted by peripheral blood granulocytes, bone marrow, spleen, intestine, and lung. RELM-γ functions to promote and regulate promyelocytic differentiation, in addition to regulating nutrient-associated insulin sensitivity in the intestinal tract. Rodents secrete all four RELM-family members, whereas resistin and RELM-β are the only RELM-family members found in humans.
MUTYH blocking peptide Reference: GTX89215-PEP This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 28]
Recombinant Human Resistin Reference: GFH107-5 Resistin is a peptide hormone belonging to a class of cysteine-rich secreted proteins, termed the resistin-like molecules (RELM) family. Resistin is produced by macrophages and functions during insulin sensitivity and inflammatory processes.
AIRE (isoforms 1 + 2) blocking peptide Reference: GTX89216-PEP This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 212]
Recombinant Human Resistin Reference: GFH107-25 Resistin is a peptide hormone belonging to a class of cysteine-rich secreted proteins, termed the resistin-like molecules (RELM) family. Resistin is produced by macrophages and functions during insulin sensitivity and inflammatory processes.
Recombinant Human Resistin Reference: GFH107-100 Resistin is a peptide hormone belonging to a class of cysteine-rich secreted proteins, termed the resistin-like molecules (RELM) family. Resistin is produced by macrophages and functions during insulin sensitivity and inflammatory processes.
Smoothened homolog (internal) blocking peptide Reference: GTX89218-PEP The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 21]
Recombinant Human Resistin Reference: GFH107-1000 Resistin is a peptide hormone belonging to a class of cysteine-rich secreted proteins, termed the resistin-like molecules (RELM) family. Resistin is produced by macrophages and functions during insulin sensitivity and inflammatory processes.
ZMPSTE24 blocking peptide Reference: GTX89219-PEP This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 28]
Recombinant Mouse Resistin Reference: GFM30-5 Resistin is a peptide hormone belonging to a class of cysteine-rich secreted proteins, termed the resistin-like molecules (RELM) family. Mouse resistin is produced by adipocytes and may be an important link between obesity and insulin resistance.