Recombinant Human RELM-β Reference: GFH160-25 Resistin-like molecule-β (RELM-β) is a member of the RELM-family of secreted proteins containing conserved C-terminus cysteines. The RELM-family consists of resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). Resistin and RELM-β are the only RELM-family members found in humans, whereas all four RELM-family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.
PRPF31 blocking peptide Reference: GTX89187-PEP This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 29]
Recombinant Human RELM-β Reference: GFH160-100 Resistin-like molecule-β (RELM-β) is a member of the RELM-family of secreted proteins containing conserved C-terminus cysteines. The RELM-family consists of resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). Resistin and RELM-β are the only RELM-family members found in humans, whereas all four RELM-family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.
RNF213 (C Terminus) blocking peptide Reference: GTX89188-PEP This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 211]
Recombinant Human RELM-β Reference: GFH160-1000 Resistin-like molecule-β (RELM-β) is a member of the RELM-family of secreted proteins containing conserved C-terminus cysteines. The RELM-family consists of resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). Resistin and RELM-β are the only RELM-family members found in humans, whereas all four RELM-family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.
GATA5 blocking peptide Reference: GTX89189-PEP The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 28]
Recombinant Human RELM-β (Animal-Free) Reference: GFH160AF-5 Resistin-like molecule-β (RELM-β) is a member of the RELM-family of secreted proteins containing conserved C-terminus cysteines. The RELM-family consists of resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). Resistin and RELM-β are the only RELM-family members found in humans, whereas all four RELM-family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.
RASAL1 blocking peptide Reference: GTX89190-PEP The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 21]
Recombinant Human RELM-β (Animal-Free) Reference: GFH160AF-25 Resistin-like molecule-β (RELM-β) is a member of the RELM-family of secreted proteins containing conserved C-terminus cysteines. The RELM-family consists of resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). Resistin and RELM-β are the only RELM-family members found in humans, whereas all four RELM-family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.
FGF23 blocking peptide Reference: GTX89195-PEP This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 213]
Recombinant Human RELM-β (Animal-Free) Reference: GFH160AF-100 Resistin-like molecule-β (RELM-β) is a member of the RELM-family of secreted proteins containing conserved C-terminus cysteines. The RELM-family consists of resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). Resistin and RELM-β are the only RELM-family members found in humans, whereas all four RELM-family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.