TEB4 / MARCH-VI (aa 701 to 712) blocking peptide Reference: GTX88852-PEP This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 212]
Recombinant Mouse MIF (Animal-Free) Reference: GFM78AF-25 Migration Inhibitory Factor (MIF) is a pro-inflammatory lymphokine that functions during cell-mediated immmunity. MIF promotes fibroblast migration by inducing interleukin-1 (IL-1), interleukin-8 (IL-8), and matrix metalloproteinase (MMP) expression. In interferon-γ-activated macrophages, MIF stimulates nitric oxide (NO) production and Tumor Necrosis Factor α (TNF-α) secretion.
GOT2 (aa 295 to 306) blocking peptide Reference: GTX88853-PEP Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 213]
Recombinant Mouse MIF (Animal-Free) Reference: GFM78AF-100 Migration Inhibitory Factor (MIF) is a pro-inflammatory lymphokine that functions during cell-mediated immmunity. MIF promotes fibroblast migration by inducing interleukin-1 (IL-1), interleukin-8 (IL-8), and matrix metalloproteinase (MMP) expression. In interferon-γ-activated macrophages, MIF stimulates nitric oxide (NO) production and Tumor Necrosis Factor α (TNF-α) secretion.
COL4A3BP (aa662-672) blocking peptide Reference: GTX88855-PEP This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 28]
Recombinant Mouse MIF (Animal-Free) Reference: GFM78AF-1000 Migration Inhibitory Factor (MIF) is a pro-inflammatory lymphokine that functions during cell-mediated immmunity. MIF promotes fibroblast migration by inducing interleukin-1 (IL-1), interleukin-8 (IL-8), and matrix metalloproteinase (MMP) expression. In interferon-γ-activated macrophages, MIF stimulates nitric oxide (NO) production and Tumor Necrosis Factor α (TNF-α) secretion.
ACTL7B blocking peptide Reference: GTX88858-PEP The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 28]
Recombinant Human MIG / CXCL9 Reference: GFH184-5 Monokine induced by γ interferon (MIG), also known as CXCL9, is a T cell chemoattractant during neuroinflammatory events. CXCL9 production is stimulated by interferon-γ (IFN-γ) and CXCL9 signals through the chemokine receptor CXCR3.
Recombinant Human MIG / CXCL9 Reference: GFH184-20 Monokine induced by γ interferon (MIG), also known as CXCL9, is a T cell chemoattractant during neuroinflammatory events. CXCL9 production is stimulated by interferon-γ (IFN-γ) and CXCL9 signals through the chemokine receptor CXCR3.
GCNT3 (aa 273 to 284) blocking peptide Reference: GTX88861-PEP This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 29]
Recombinant Human MIG / CXCL9 Reference: GFH184-100 Monokine induced by γ interferon (MIG), also known as CXCL9, is a T cell chemoattractant during neuroinflammatory events. CXCL9 production is stimulated by interferon-γ (IFN-γ) and CXCL9 signals through the chemokine receptor CXCR3.