BAG5 blocking peptide Reference: GTX88490-PEP The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 7 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc7/Hsp7. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 28]
Recombinant Human IL-19 (Animal-Free) Reference: GFH88AF-100 Interleukin-19 (IL-19) is a member of the interleukin-10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin-20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin-6 (IL-6) and Tumor Necrosis Factor α (TNF-α) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.
Recombinant Human IL-19 (Animal-Free) Reference: GFH88AF-1000 Interleukin-19 (IL-19) is a member of the interleukin-10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin-20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin-6 (IL-6) and Tumor Necrosis Factor α (TNF-α) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.
GAD67 blocking peptide Reference: GTX88492-PEP This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 28]
Recombinant Mouse IL-19 Reference: GFM75-2 Interleukin-19 (IL-19) is a member of the interleukin-10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin-20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin-6 (IL-6) and Tumor Necrosis Factor α (TNF-α) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.
CDKAL1 blocking peptide Reference: GTX88493-PEP The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 21]
Recombinant Mouse IL-19 Reference: GFM75-10 Interleukin-19 (IL-19) is a member of the interleukin-10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin-20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin-6 (IL-6) and Tumor Necrosis Factor α (TNF-α) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.
ARPC4 blocking peptide Reference: GTX88495-PEP This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p2 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 21]
Recombinant Mouse IL-19 Reference: GFM75-100 Interleukin-19 (IL-19) is a member of the interleukin-10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin-20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin-6 (IL-6) and Tumor Necrosis Factor α (TNF-α) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.
Ferritin Light Chain blocking peptide Reference: GTX88496-PEP This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 28]
Recombinant Mouse IL-19 Reference: GFM75-1000 Interleukin-19 (IL-19) is a member of the interleukin-10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin-20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin-6 (IL-6) and Tumor Necrosis Factor α (TNF-α) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.