EWSR1 blocking peptide Reference: GTX88471-PEP This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 29]
Recombinant Mouse IL-17F (Animal-Free) Reference: GFM62AF-100 Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor β 1 (TGF-β1).
BMAL1 blocking peptide Reference: GTX88473-PEP The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 214]
Recombinant Mouse IL-17F (Animal-Free) Reference: GFM62AF-1000 Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor β 1 (TGF-β1).
PXR blocking peptide Reference: GTX88474-PEP This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P45 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 28]
Recombinant Rat IL-17F Reference: GFR28-5 Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor β 1 (TGF-β1).
PCQAP / MED15 blocking peptide Reference: GTX88475-PEP The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 28]
Recombinant Rat IL-17F Reference: GFR28-25 Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor β 1 (TGF-β1).
Annexin A1 blocking peptide Reference: GTX88476-PEP This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 214]
Recombinant Rat IL-17F Reference: GFR28-100 Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor β 1 (TGF-β1).
SFRP4 blocking peptide Reference: GTX88477-PEP Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 28]
Recombinant Rat IL-17F Reference: GFR28-1000 Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor β 1 (TGF-β1).