Podoplanin blocking peptide Reference: GTX88363-PEP This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 28]
Recombinant Mouse IL-11 (Animal-Free) Reference: GFM64AF-100 Interleukin-11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling.
UBR4 blocking peptide Reference: GTX88365-PEP The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 21]
Recombinant Mouse IL-11 (Animal-Free) Reference: GFM64AF-1000 Interleukin-11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling.
PRKCDBP blocking peptide Reference: GTX88367-PEP The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 28]
Recombinant Mouse IL-12 Reference: GFM25-2 Interleukin-12 (IL-12) is an inducer of cell-mediated immunity and is produced by dendritic cells, macrophages, and B cells after antigen stimulation. IL-12 functions to promote naive T cell differentiation into the type 1 T helper cell (Th1) lineage. IL-12 also stimulates the production of interferon-γ (IFN-γ) and Tumor Necrosis Factor α (TNF-α) from T cells and Natural Killer cells. Mouse IL-12 is active on human and mouse cells.
Recombinant Mouse IL-12 Reference: GFM25-10 Interleukin-12 (IL-12) is an inducer of cell-mediated immunity and is produced by dendritic cells, macrophages, and B cells after antigen stimulation. IL-12 functions to promote naive T cell differentiation into the type 1 T helper cell (Th1) lineage. IL-12 also stimulates the production of interferon-γ (IFN-γ) and Tumor Necrosis Factor α (TNF-α) from T cells and Natural Killer cells. Mouse IL-12 is active on human and mouse cells.
Calnexin blocking peptide Reference: GTX88369-PEP This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 28]
Recombinant Mouse IL-12 Reference: GFM25-100 Interleukin-12 (IL-12) is an inducer of cell-mediated immunity and is produced by dendritic cells, macrophages, and B cells after antigen stimulation. IL-12 functions to promote naive T cell differentiation into the type 1 T helper cell (Th1) lineage. IL-12 also stimulates the production of interferon-γ (IFN-γ) and Tumor Necrosis Factor α (TNF-α) from T cells and Natural Killer cells. Mouse IL-12 is active on human and mouse cells.
SUMF1 blocking peptide Reference: GTX88370-PEP This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 29]
Recombinant Mouse IL-12 Reference: GFM25-1000 Interleukin-12 (IL-12) is an inducer of cell-mediated immunity and is produced by dendritic cells, macrophages, and B cells after antigen stimulation. IL-12 functions to promote naive T cell differentiation into the type 1 T helper cell (Th1) lineage. IL-12 also stimulates the production of interferon-γ (IFN-γ) and Tumor Necrosis Factor α (TNF-α) from T cells and Natural Killer cells. Mouse IL-12 is active on human and mouse cells.