FOXP2 (C terminus) blocking peptide Reference: GTX47606-PEP This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 3 to 4 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 21]
Recombinant Rat Activin A (Animal-Free) Reference: GFR6AF-2 Activin A is a member of the Transforming Growth Factor β (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin β A chains. Rat Activin A shares 100% amino acid sequence identity with human, mouse, porcine, bovine, and feline Activin A proteins.
Recombinant Rat Activin A (Animal-Free) Reference: GFR6AF-10 Activin A is a member of the Transforming Growth Factor β (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin β A chains. Rat Activin A shares 100% amino acid sequence identity with human, mouse, porcine, bovine, and feline Activin A proteins.
DUSP1 blocking peptide Reference: GTX47608-PEP The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 28]
Recombinant Rat Activin A (Animal-Free) Reference: GFR6AF-100 Activin A is a member of the Transforming Growth Factor β (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin β A chains. Rat Activin A shares 100% amino acid sequence identity with human, mouse, porcine, bovine, and feline Activin A proteins.
SLC7A10 blocking peptide Reference: GTX47874-PEP transports D- and L-serine with high affinity; may be essential for survival and dendrite growth of Purkinje neurons [RGD, Feb 26]
Recombinant Rat Activin A (Animal-Free) Reference: GFR6AF-1000 Activin A is a member of the Transforming Growth Factor β (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin β A chains. Rat Activin A shares 100% amino acid sequence identity with human, mouse, porcine, bovine, and feline Activin A proteins.
Recombinant Human Artemin Reference: GFH23-5 Artemin is a Neurotrophin member of the Glial cell line-derived Neurotrophic Factor (GDNF) ligand family. Artemin is highly expressed in the adult pituitary gland, placenta, and trachea, and shows low level expression in the brain, spinal cord, and peripheral tissues. Artemin signals through the RET receptor and GDNF family receptor α 3 (GFR α 3) co-receptor complex to support neuronal survival.
Recombinant Human Artemin Reference: GFH23-20 Artemin is a Neurotrophin member of the Glial cell line-derived Neurotrophic Factor (GDNF) ligand family. Artemin is highly expressed in the adult pituitary gland, placenta, and trachea, and shows low level expression in the brain, spinal cord, and peripheral tissues. Artemin signals through the RET receptor and GDNF family receptor α 3 (GFR α 3) co-receptor complex to support neuronal survival.