Category: Proteins & Peptides

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Reference: GTX32001-PEP

Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 143). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 14311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 1476) C-terminal fragment (APP-CTF) (He et al., 21 [PubMed 2811458]).[supplied by OMIM, Nov 21]

Reference: 32038-20

Recombinant human N-terminal His-GST-tagged PDE4B2 expressed in insect cells • Amino acids: 1-564 • MW: 92.2 kDa

Reference: 32038-50

Recombinant human N-terminal His-GST-tagged PDE4B2 expressed in insect cells • Amino acids: 1-564 • MW: 92.2 kDa

Reference: 32039-100

Source: Recombinant human N-terminal His-GST-tagged PDE9A2 expressed in insect cells • Amino acids: 1-533 (full length) • MW: 89.5 kDa