Recombinant Human Transforming growth factor beta-3(TGFB3),partial Reference: CSB-EP023449HU_20 Involved in embryogenesis and cell differentiation.
Recombinant Human Transforming growth factor beta-3(TGFB3),partial Reference: CSB-EP023449HU1_1 Involved in bryogenesis and cell differentiation.
Recombinant Human Transforming growth factor beta-3(TGFB3),partial Reference: CSB-EP023449HU1_100 Involved in bryogenesis and cell differentiation.
Recombinant Human Transforming growth factor beta-3(TGFB3),partial Reference: CSB-EP023449HU1_20 Involved in bryogenesis and cell differentiation.
Recombinant Rat TGF-beta receptor type-2(Tgfbr2),partial Reference: CSB-EP023452RA1_1 Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Recombinant Rat TGF-beta receptor type-2(Tgfbr2),partial Reference: CSB-EP023452RA1_100 Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Recombinant Rat TGF-beta receptor type-2(Tgfbr2),partial Reference: CSB-EP023452RA1_20 Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Recombinant Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) Reference: CSB-EP023462HU_1 Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Recombinant Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) Reference: CSB-EP023462HU_100 Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Recombinant Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) Reference: CSB-EP023462HU_20 Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Recombinant Human Thrombomodulin(THBD),partial Reference: CSB-EP023486HU2_1 Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Recombinant Human Thrombomodulin(THBD),partial Reference: CSB-EP023486HU2_100 Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.