TIP60 (human, recombinant) Reference: 10783-100 Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells • TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant protein kinase.
TAB2 blocking peptide Reference: GTX31692-PEP The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq, Jul 28]
PAD1 (human, recombinant) Reference: 10784-100 Source: Recombinant N-terminal His-tagged protein expressed in E. coli • MW: 76.4 kDa
TAB3 blocking peptide Reference: GTX31693-PEP The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 28]
BTK blocking peptide Reference: GTX31694-PEP The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 213]
IRF3 blocking peptide Reference: GTX31695-PEP This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 211]
Autotaxin (human recombinant) Reference: 10803-100 Source: recombinant C-terminal histidine-tagged protein expressed using a baculovirus overexpression system in Sf21 cells • Mr: 98.8 kDa • A secreted lysophospholipase D that catalyzes the hydrolysis of LPC to generate LPA; ATX-LPA signaling is involved in a range of pathologies including tumor progession and inflammation; it is proteolytically processed by cleavage of a 35 amino acid signal peptide and then secreted as a mature protein
IRF8 blocking peptide Reference: GTX31696-PEP Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 28]
WDR5 (human, recombinant) Reference: 10944-100 Source: Recombinant protein expressed in E. coli • WDR5 has been demonstrated to bind histone H3 by recognizing the first three amino acids of the N-terminal tail. Binding of WDR5 to a conserved arginine-containing motif in MLL-1, the so-called WDR5 interaction (“Win”) motif, promotes the assembly and activity of the MLL core complex.
Bim blocking peptide Reference: GTX31697-PEP The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jul 28]