TGF-beta1, human recombinant protein (CHO cells) Reference: P1039-.5 TGF-β1, pleiotropic cytokine, expressed in CHO cells.
CIITA blocking peptide Reference: GTX31419-PEP This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 213]
TPO, human recombinant protein Reference: P1040-.01 TPO, cytokines, expressed in E.Coli, cross-species reactivity.
KPNA3 blocking peptide Reference: GTX31420-PEP The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 6-1 proteins. Small molecules (up to 7 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 29]
TPO, human recombinant protein Reference: P1040-.05 TPO, cytokines, expressed in E.Coli, cross-species reactivity.
TRIP6 blocking peptide Reference: GTX31421-PEP This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 28]
TPO, human recombinant protein Reference: P1040-1 TPO, cytokines, expressed in E.Coli, cross-species reactivity.
Trefoil Factor 3 blocking peptide Reference: GTX31422-PEP Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 4-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 28]
VEGF165, human recombinant protein Reference: P1041-.01 VEGF165, vascular permeability factor, expressed in E.Coli.
VEGF165, human recombinant protein Reference: P1041-.05 VEGF165, vascular permeability factor, expressed in E.Coli.
FBXL16 blocking peptide Reference: GTX31424-PEP Members of the F-box protein family, such as FBXL16, are characterized by an approximately 4-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 61434), cullin (see CUL1; MIM 63134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 24 [PubMed 1552277]).[supplied by OMIM, Mar 28]