TNF-alpha, recombinant murine protein Reference: P1002-.01 TNF-α, expressed in E. coli, suitable for cell culture.
CD82 blocking peptide Reference: GTX31310-PEP This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 28]
TNF-alpha, recombinant murine protein Reference: P1002-.05 TNF-α, expressed in E. coli, suitable for cell culture.
SIN1 blocking peptide Reference: GTX31311-PEP This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 28]
TNF-alpha, recombinant murine protein Reference: P1002-1 TNF-α, expressed in E. coli, suitable for cell culture.
SIN1 blocking peptide Reference: GTX31312-PEP This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 28]
TNF-alpha, recombinant rat protein Reference: P1003-.01 TNF-α, expressed in E. coli, suitable for cell culture.
Presenilin 1 blocking peptide Reference: GTX31313-PEP Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 28]
TNF-alpha, recombinant rat protein Reference: P1003-.05 TNF-α, expressed in E. coli, suitable for cell culture.
BUB3 blocking peptide Reference: GTX31314-PEP This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 28]
TNF-alpha, recombinant rat protein Reference: P1003-1 TNF-α, expressed in E. coli, suitable for cell culture.
IEX1 blocking peptide Reference: GTX31315-PEP This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 28]