ILP2 peptide Reference: GTX29665 Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
Aurora A blocking peptide Reference: GTX29689-PEP The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 1. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 28]
ITK blocking peptide Reference: GTX29707-PEP This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 28]
tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] Reference: A1094-1 P53 binding protein fragment
p53DINP1 peptide Reference: GTX29776 In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.
tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] Reference: A1094-5 P53 binding protein fragment
Streptomycin control peptide Reference: GTX30733 Control peptide for Streptomycin [1.BB.944] antibody (GTX1571)
tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] Reference: A1094-10 P53 binding protein fragment
GPR120 peptide Reference: GTX30752 GPR12 is an Orphan-A GPCR with no known ligand. An EST has been isolated from a human colon cancer library.