Acinus peptide Reference: GTX28369 Chromatin condensation and nuclear fragmentation (CCNF)is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF4), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS.
Acinus peptide Reference: GTX28370 Chromatin condensation and nuclear fragmentation (CCNF)is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF4), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS.
NOL3 peptide Reference: GTX28371 Nucleolar protein 3 (Nop3) is coded by the Arc gene. The nuclear isoform of Nop3 (1/Nop3)may be involved in RNA splicing and the cytoplasmic isoform (2/Myp) may inhibit apoptosis. Isoform 1 oligomerizes and binds to SFRS9/SRp3C and also interacts with NPM1. Isoform 2 binds caspase 2, caspase 8 and CED3 and inhibits caspase 8 activity. Nop3 isoform 1 is found in nucleoli and nucleoplasm. Nop3 isoform 2 is cytoplasmic. Nop3 is highly expressed in heart and skeletal muscle with lower levels detected in placenta, liver, kidney and pancreas
NOL3 peptide Reference: GTX28372 Nucleolar protein 3 (Nop3) is coded by the Arc gene. The nuclear isoform of Nop3 (1/Nop3)may be involved in RNA splicing and the cytoplasmic isoform (2/Myp) may inhibit apoptosis. Isoform 1 oligomerizes and binds to SFRS9/SRp3C and also interacts with NPM1. Isoform 2 binds caspase 2, caspase 8 and CED3 and inhibits caspase 8 activity. Nop3 isoform 1 is found in nucleoli and nucleoplasm. Nop3 isoform 2 is cytoplasmic. Nop3 is highly expressed in heart and skeletal muscle with lower levels detected in placenta, liver, kidney and pancreas.
Caspase 12 peptide Reference: GTX28374 Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main ways in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is colocalized to the ER with several proteins that are involved in Alzheimers disease including g-secretase presenilin and b-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues.