Category: Proteins & Peptides

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Fibrinogen Binding Inhibitor Peptide Fibrinogen Binding Inhibitor Peptide

Fibrinogen Binding Inhibitor Peptide

Reference: HY-P1507
€0.00 (tax incl.)
Fibrinogen Binding Inhibitor Peptide is a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411). Fibrinogen Binding Inhibitor Peptide is a specific binding site of the...
Boc-Glu-OtBu Boc-Glu-OtBu

Boc-Glu-OtBu

Reference: HY-W007354
€0.00 (tax incl.)
Boc-Glu-OtBu is a glutamic acid derivative.
Human CHMP2A protein, His tag Human CHMP2A protein, His tag

Human CHMP2A protein, His tag

Reference: GTX68402-pro
€0.00 (tax incl.)
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex...
Lonodelestat TFA Lonodelestat TFA

Lonodelestat TFA

Reference: HY-P3293A
€0.00 (tax incl.)
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF).
Human PDCD4 protein Human PDCD4 protein

Human PDCD4 protein

Reference: GTX68403-pro
€0.00 (tax incl.)
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple...
WAY-181187 oxalate WAY-181187 oxalate

WAY-181187 oxalate

Reference: HY-110366
€0.00 (tax incl.)
WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and...
Human PDCD4 protein, His tag Human PDCD4 protein, His tag

Human PDCD4 protein, His tag

Reference: GTX68404-pro
€0.00 (tax incl.)
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple...
TT-232 TT-232

TT-232

Reference: HY-105172
€0.00 (tax incl.)
TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent.
Lobradimil Lobradimil

Lobradimil

Reference: HY-105155
€0.00 (tax incl.)
Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of...
Human LSM1 protein, His tag Human LSM1 protein, His tag

Human LSM1 protein, His tag

Reference: GTX68406-pro
€0.00 (tax incl.)
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by...
Human LSM3 protein, His tag Human LSM3 protein, His tag

Human LSM3 protein, His tag

Reference: GTX68407-pro
€0.00 (tax incl.)
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 6161). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions...
Human SULT1B1 protein, His tag Human SULT1B1 protein, His tag

Human SULT1B1 protein, His tag

Reference: GTX68408-pro
€0.00 (tax incl.)
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate...
FSL-1 FSL-1

FSL-1

Reference: HY-P2036
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FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
Human DIMT1 protein, His tag Human DIMT1 protein, His tag

Human DIMT1 protein, His tag

Reference: GTX68409-pro
€0.00 (tax incl.)
The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although...
α-Casein (90-95) α-Casein (90-95)

α-Casein (90-95)

Reference: HY-P1793
€0.00 (tax incl.)
α-Casein (90-95) is a peptide fragment of α-Casein.
Human CRCP protein, His tag Human CRCP protein, His tag

Human CRCP protein, His tag

Reference: GTX68410-pro
€0.00 (tax incl.)
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different...
Human HPGDS protein, His tag Human HPGDS protein, His tag

Human HPGDS protein, His tag

Reference: GTX68411-pro
€0.00 (tax incl.)
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast...
Pepstatin Pepstatin

Pepstatin

Reference: HY-P0018
€0.00 (tax incl.)
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase,...
Human EIF3K protein, His tag Human EIF3K protein, His tag

Human EIF3K protein, His tag

Reference: GTX68412-pro
€0.00 (tax incl.)
The 7-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 4S ribosomal...
DAMGO TFA DAMGO TFA

DAMGO TFA

Reference: HY-P0210B
€0.00 (tax incl.)
DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR.
Human UBE2S protein, His tag Human UBE2S protein, His tag

Human UBE2S protein, His tag

Reference: GTX68413-pro
€0.00 (tax incl.)
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic...
Fmoc-N-Me-Glu(OtBu)-OH Fmoc-N-Me-Glu(OtBu)-OH

Fmoc-N-Me-Glu(OtBu)-OH

Reference: HY-W008529
€0.00 (tax incl.)
Fmoc-N-Me-Glu(OtBu)-OH is a glutamic acid derivative.
Human DNA polymerase lambda protein, His tag Human DNA polymerase lambda protein, His tag

Human DNA polymerase lambda protein, His tag

Reference: GTX68414-pro
€0.00 (tax incl.)
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays...
Amylin (IAPP), feline TFA Amylin (IAPP), feline TFA

Amylin (IAPP), feline TFA

Reference: HY-P1871A
€0.00 (tax incl.)
Amylin (IAPP), feline TFA is a 37-amino acid polypeptide from feline. Amylin (IAPP), feline TFA is one of the major secretory products of β-cells of the pancreatic islets. Amylin (IAPP), feline TFA is a regulatory...
Human MAT2B protein Human MAT2B protein

Human MAT2B protein

Reference: GTX68416-pro
€0.00 (tax incl.)
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit...
Lysipressin Lysipressin

Lysipressin

Reference: HY-P0004
€0.00 (tax incl.)
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.
[pTyr5] EGFR (988-993) [pTyr5] EGFR (988-993)

[pTyr5] EGFR (988-993)

Reference: HY-P1799
€0.00 (tax incl.)
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive...
Biotin-Glucagon-Like Peptide 1 (7-36) amide, human Biotin-Glucagon-Like Peptide 1 (7-36) amide, human

Biotin-Glucagon-Like Peptide 1 (7-36) amide, human

Reference: HY-P3623
€0.00 (tax incl.)
Biotin-Glucagon-Like Peptide 1 (7-36) amide, human is a biologically active peptide. Biotin-Glucagon-Like Peptide 1 (7-36) amide, human can be used for the research of various biochemical studies.
Human LAMTOR2 protein, His tag Human LAMTOR2 protein, His tag

Human LAMTOR2 protein, His tag

Reference: GTX68419-pro
€0.00 (tax incl.)
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the...
[Asu1,6-Arg8]Vasopressin [Asu1,6-Arg8]Vasopressin

[Asu1,6-Arg8]Vasopressin

Reference: HY-P4012
€0.00 (tax incl.)
[Asu1,6-Arg8]Vasopressin is an vasopressin agonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture.
Human LAMTOR2 protein, His tag Human LAMTOR2 protein, His tag

Human LAMTOR2 protein, His tag

Reference: GTX68420-pro
€0.00 (tax incl.)
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the...
Human DCPS protein, His tag Human DCPS protein, His tag

Human DCPS protein, His tag

Reference: GTX68421-pro
€0.00 (tax incl.)
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′...
HIV Protease Substrate I HIV Protease Substrate I

HIV Protease Substrate I

Reference: HY-P3934
€0.00 (tax incl.)
HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease.
MMI-0100 MMI-0100

MMI-0100

Reference: HY-P3412
€0.00 (tax incl.)
MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression...
Human NOB1 protein, His tag Human NOB1 protein, His tag

Human NOB1 protein, His tag

Reference: GTX68423-pro
€0.00 (tax incl.)
In yeast, over 2 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA...
LCKLSL hydrochloride LCKLSL hydrochloride

LCKLSL hydrochloride

Reference: HY-P2333A
€0.00 (tax incl.)
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL hydrochloride...
Human MRPL13 protein, His tag Human MRPL13 protein, His tag

Human MRPL13 protein, His tag

Reference: GTX68424-pro
€0.00 (tax incl.)
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S...
Z-D-Ser-OH Z-D-Ser-OH

Z-D-Ser-OH

Reference: HY-W012104
€0.00 (tax incl.)
Z-D-Ser-OH is a serine derivative.
Human HRPAP20 protein, His tag Human HRPAP20 protein, His tag

Human HRPAP20 protein, His tag

Reference: GTX68425-pro
€0.00 (tax incl.)
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons...
Calmodulin-Dependent Protein Kinase II (290-309) Calmodulin-Dependent Protein Kinase II (290-309)

Calmodulin-Dependent Protein Kinase II (290-309)

Reference: HY-P1479
€0.00 (tax incl.)
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
Human MED4 protein, His tag Human MED4 protein, His tag

Human MED4 protein, His tag

Reference: GTX68426-pro
€0.00 (tax incl.)
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced...
Boc-Phe(4-Br)-OH Boc-Phe(4-Br)-OH

Boc-Phe(4-Br)-OH

Reference: HY-W011178
€0.00 (tax incl.)
Boc-Phe(4-Br)-OH is a phenylalanine derivative.
Human PHPT1 protein, His tag Human PHPT1 protein, His tag

Human PHPT1 protein, His tag

Reference: GTX68427-pro
€0.00 (tax incl.)
This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating...
5-Bromo-L-tryptophan 5-Bromo-L-tryptophan

5-Bromo-L-tryptophan

Reference: HY-20897A
€0.00 (tax incl.)
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp..
Cyclo(L-Phe-L-Pro) Cyclo(L-Phe-L-Pro)

Cyclo(L-Phe-L-Pro)

Reference: HY-P1934A
€0.00 (tax incl.)
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with...
Human THYN1 protein, His tag Human THYN1 protein, His tag

Human THYN1 protein, His tag

Reference: GTX68429-pro
€0.00 (tax incl.)
This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have...
DL-Valine DL-Valine

DL-Valine

Reference: HY-W012889
€0.00 (tax incl.)
DL-Valine is a valine derivative.
Human UBE2T protein, His tag Human UBE2T protein, His tag

Human UBE2T protein, His tag

Reference: GTX68430-pro
€0.00 (tax incl.)
The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants...
Methionylserine Methionylserine

Methionylserine

Reference: HY-W012159
€0.00 (tax incl.)
Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM....
Human Amisyn protein, His tag Human Amisyn protein, His tag

Human Amisyn protein, His tag

Reference: GTX68431-pro
€0.00 (tax incl.)
STXBP6 binds components of the SNARE complex (see MIM 63215) and may be involved in regulating SNARE complex formation (Scales et al., 22 [PubMed 12145319]).[supplied by OMIM, Mar 28]
Tyr0-Neurokinin B Tyr0-Neurokinin B

Tyr0-Neurokinin B

Reference: HY-P3847
€0.00 (tax incl.)
Tyr0-Neurokinin B (Tyr-NKB) is an analogue of Neurokinin B. Tyr0-Neurokinin B can exerts contractions in bladder.
RGDV RGDV

RGDV

Reference: HY-P3052
€0.00 (tax incl.)
RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect.
Human MOG1 protein, His tag Human MOG1 protein, His tag

Human MOG1 protein, His tag

Reference: GTX68434-pro
€0.00 (tax incl.)
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative...
Onvitrelin ucalontide Onvitrelin ucalontide

Onvitrelin ucalontide

Reference: HY-P4144
€0.00 (tax incl.)
Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is an analogue of luteinizing hormone releasing hormone (LHRH) with antineoplastic activity. Onvitrelin ucalontide is a peptide with sequences of...
SAH-SOS1A TFA SAH-SOS1A TFA

SAH-SOS1A TFA

Reference: HY-P2265A
€0.00 (tax incl.)
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). SAH-SOS1A TFA...
Human HEMK2 protein, His tag Human HEMK2 protein, His tag

Human HEMK2 protein, His tag

Reference: GTX68437-pro
€0.00 (tax incl.)
This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting...
Autocamtide 2, amide Autocamtide 2, amide

Autocamtide 2, amide

Reference: HY-P1528
€0.00 (tax incl.)
Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays.
Human NXT1 protein, His tag Human NXT1 protein, His tag

Human NXT1 protein, His tag

Reference: GTX68438-pro
€0.00 (tax incl.)
The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear...
Z-LEHD-FMK TFA Z-LEHD-FMK TFA

Z-LEHD-FMK TFA

Reference: HY-P1010A
€0.00 (tax incl.)
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal...
Boc-D-Thr-OH Boc-D-Thr-OH

Boc-D-Thr-OH

Reference: HY-W008800
€0.00 (tax incl.)
Boc-D-Thr-OH is a threonine derivative.
Human Galectin 13 protein, His tag Human Galectin 13 protein, His tag

Human Galectin 13 protein, His tag

Reference: GTX68440-pro
€0.00 (tax incl.)
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical...
Phytochelatin 3 TFA Phytochelatin 3 TFA

Phytochelatin 3 TFA

Reference: HY-P3320A
€0.00 (tax incl.)
Phytochelatin 3 (PC 3) TFA is the small metal chelating peptide that can be used for chelating heavy metals.
Rat PRX II protein, His tag Rat PRX II protein, His tag

Rat PRX II protein, His tag

Reference: GTX68441-pro
€0.00 (tax incl.)
protective enzyme against oxidative damage by cellular reactive sulfur species [RGD, Feb 26]
Neuromedin U, rat TFA Neuromedin U, rat TFA

Neuromedin U, rat TFA

Reference: HY-P1238A
€0.00 (tax incl.)
Neuromedin U, rat TFA is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy...
Human BLNK protein, His tag Human BLNK protein, His tag

Human BLNK protein, His tag

Reference: GTX68442-pro
€0.00 (tax incl.)
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby...
β-Amyloid (12-20) β-Amyloid (12-20)

β-Amyloid (12-20)

Reference: HY-P1880
€0.00 (tax incl.)
β-Amyloid (12-20) is a peptide fragment of β-Amyloid.
SN50 SN50

SN50

Reference: HY-P0151
€0.00 (tax incl.)
SN50 is a cell permeable inhibitor of NF-κB translocation.
Human GTPBP9 protein, His tag Human GTPBP9 protein, His tag

Human GTPBP9 protein, His tag

Reference: GTX68444-pro
€0.00 (tax incl.)
This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome...
Jagged-1 (188-204) (TFA) Jagged-1 (188-204) (TFA)

Jagged-1 (188-204) (TFA)

Reference: HY-P1846A
€0.00 (tax incl.)
Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces...
Marlumotide Marlumotide

Marlumotide

Reference: HY-P4151
€0.00 (tax incl.)
Marlumotide is an immunological agent for active immunization, as well as an antineoplastic agent.
Human eEF2K protein, His tag Human eEF2K protein, His tag

Human eEF2K protein, His tag

Reference: GTX68446-pro
€0.00 (tax incl.)
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein...
Globomycin Globomycin

Globomycin

Reference: HY-P2233
€0.00 (tax incl.)
Globomycin is a lipopeptide antibiotic and a signal peptidase II (LspA) inhibitor. Globomycin inhibits processing of the prolipoprotein by binding irreversibly to the peptidase. Globomycin has toxic for the mollicute...
Human PYCR2 protein, His tag Human PYCR2 protein, His tag

Human PYCR2 protein, His tag

Reference: GTX68447-pro
€0.00 (tax incl.)
This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis....
Histone H4 (2-21) Histone H4 (2-21)

Histone H4 (2-21)

Reference: HY-P1958
€0.00 (tax incl.)
Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes.
Human DNMT3L protein, His tag Human DNMT3L protein, His tag

Human DNMT3L protein, His tag

Reference: GTX68448-pro
€0.00 (tax incl.)
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian...

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