Human Nanog protein Reference: GTX68749-pro The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 215]
Human OBFC1 protein, His tag Reference: GTX68750-pro OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 29 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF16; MIM 61313) (Miyake et al., 29 [PubMed 1985413]).[supplied by OMIM, Nov 29]
Human PTGES2 protein, His tag Reference: GTX68752-pro The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 29]
Human SIKE1 protein, His tag Reference: GTX68753-pro SIKE interacts with IKK-epsilon (IKBKE; MIM 6548) and TBK1 (MIM 64834) and acts as a suppressor of TLR3 (MIM 6329) and virus-triggered interferon activation pathways (Huang et al., 25 [PubMed 1628157]).[supplied by OMIM, Mar 28]