I-TAC (CXCL11), human, Reference: C-67820 Recombinant Human Interferon-inducible T-cell alpha Chemoattractant (CXCL11)
IL17 Receptor alpha blocking peptide Reference: GTX16598-PEP Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. [provided by RefSeq, Jul 28]
LEC (CCL16, NCC-4), human, recombinant Reference: C-67830 Recombinant Human Liver-Expressed Chemokine (CCL16, NCC-4)
SnoN blocking peptide Reference: GTX16977-PEP The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 211]
MDC (CCL22, 67 aa), human, Reference: C-67910 Recombinant Human Macrophage Derived Chemokine (67 amino acid variant)
DEDD2 blocking peptide Reference: GTX16979-PEP This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 212]
MDC (CCL22, 69 aa), human, recombinant Reference: C-67920 Recombinant Human Macrophage Derived Chemokine (69 amino acid variant)
BIRC6 blocking peptide Reference: GTX16980-PEP This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 28]
MEC (CCL28), human, recombinant Reference: C-67940 Recombinant Human Mucosae Associated Epithelial Chemokine (CCL28)
Bok blocking peptide Reference: GTX16981-PEP The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 211]
AES blocking peptide Reference: GTX16982-PEP The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 28]