DUSP16 blocking peptide Reference: GTX15698-PEP This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 21]
GDF-11, human, recombinant Reference: C-67328 Recombinant Human/Mouse/Rat Growth & Differentiation Factor 11
Wnt4 blocking peptide Reference: GTX15699-PEP The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 28]
GDF-15 (MIC-1), human, recombinant Reference: C-67329 Recombinant Human Growth & Differentiation Factor 15 (MIC-1)
GDF-5, human, recombinant Reference: C-67330 Recombinant Human Growth & Differentiation Factor 5 (BMP-14)
CPT1B (isoform 1) blocking peptide Reference: GTX15703-PEP The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 29]
GDF-7, human, recombinant Reference: C-67332 Recombinant Human Growth & Differentiation Factor 7 (BMP-12)
Growth Hormone (GH), human, Reference: C-67334 Recombinant Human Growth Hormone (GH; HEK cell-derived)
CLPP blocking peptide Reference: GTX15708-PEP The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 28]