BMP-2, human, recombinant Reference: C-67309 Recombinant Human Bone Morphogenetic Protein 2 (HEK cell-derived)
p70 S6K blocking peptide Reference: GTX14708-PEP This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 213]
BMP-2, human, recombinant Reference: C-67310 Recombinant Human Bone Morphogenetic Protein 2 (E. coli-derived)
BS69 blocking peptide Reference: GTX14747-PEP The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 28]
BMP-2, human, recombinant Reference: C-67310A Recombinant Human Bone Morphogenetic Protein 2 (plant-derived)
MID2 blocking peptide Reference: GTX14749-PEP The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 29]
BMP-4, human, recombinant Reference: C-67313 Recombinant Human Bone Morphogenetic Protein 4 (HEK cell-derived)
RNF2 blocking peptide Reference: GTX14751-PEP Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 28]
BMP-4, human, recombinant Reference: C-67314 Recombinant Human Bone Morphogenetic Protein 4 (E. coli-derived)
ETEA blocking peptide Reference: GTX14759-PEP The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 28]
Coronin 1A blocking peptide Reference: GTX14787-PEP This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 4 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 21]