Recombinant Human ATPase ASNA1(ASNA1)

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmbrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by mbrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA mbrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the mbrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting . May be involved in insulin signaling.