Human CHMP5 protein, His tag

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 1641), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 26 [PubMed 1673941]).[supplied by OMIM, Mar 28]