Ku70 blocking peptide

The p7/p8 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 7 and 8 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p7 and p8 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 28]