SIGLEC8 blocking peptide

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 15959)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 64964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 63492) that mediates an association with SLAM-associated protein (SAP; MIM 349) (summarized by Foussias et al., 2 [PubMed 1195983]).[supplied by OMIM, May 21]