PION blocking peptide

Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 143). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 14311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 1476) C-terminal fragment (APP-CTF) (He et al., 21 [PubMed 2811458]).[supplied by OMIM, Nov 21]