UBA2 blocking peptide

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 61912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 99283]).[supplied by OMIM, Mar 21]