Category: Antibodies

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Reference: HY-P99496

Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis).

Reference: ARG30328

Angiogenesis antibody; Collagen IV antibody; CD34 antibody; NG2 / Chondroitin sulfate proteoglycan 4 antibody; alpha smooth muscle Actin antibody

Reference: HY-P99736

Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (KD: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II.

Reference: ARG30330

Pyroptosis antibody; GSDMD antibody; Caspase 1 antibody; beta Tubulin antibody; IL1 beta antibody

Reference: HY-P9951A

Ranibizumab (RG-6321) (anti-VEGF) is a humanized anti-VEGF monoclonal antibody fragment and can recognize all VEGF-A isoforms (VEGF110, VEGF121, and VEGF165). Ranibizumab (anti-VEGF) slows vision loss in vivo and is used for wet age-related macular degeneration (AMD) research.

Reference: ARG30331

NLRP3 Inflammasome antibody; GAPDH antibody; NALP3 / Cryopyrin antibody; Caspase 1 antibody; ASC / TMS1 antibody

Reference: HY-P99168

Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research.

Reference: ARG30332

NLRC4 Inflammasome antibody; GAPDH antibody; Caspase 1 antibody; NLRC4 / CARD12 antibody; ASC / TMS1 antibody

Reference: HY-P99203

Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research.

Reference: HY-P9967

Aducanumab (BIIB037), a human monoclonal antibody selective for aggregated forms of amyloid beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research.