Rabbit anti-Human IFN-α(CAP) Reference: RM17773 Interferon-Alpha 2a (IFN-Alpha 2a), Human produced by leukocytes is a member of Interferon family. IFN-alpha is mainly involved in innate immune response against a broad range of viral infections. IFN-alpha 2 has three acid stable forms (a,b,c) signaling through IFNAR2. IFN-alpha 2a shares 99.4% , 98.8% aa sequence identity with IFN-alpha 2b and 2c respectively. IFN-alpha contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity.
Reference: RM17609 The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It''s been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Rabbit anti-SARS-CoV-2 Nucleocapsid Protein mAb(CAP) Reference: RM17618 Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
ATM signaling pathway Antibody Panel (ATM, ATR, p53, BRCA1, CtIP, CHK1, CHK2,... Reference: GTX300053
Human AR Ultrasensitive Antibody Pair Reference: RMH-AR-96 Bead-conjugated antibody pair compatible with Simoa® (single molecule array) and similar assays for detecting human AR in various sample types. The kit includes a bottle of capture beads, a bottle of detection reagent and standards.
Human BDNF Ultrasensitive Antibody Pair Reference: RMH-BDNF-96 Bead-conjugated antibody pair compatible with Simoa® (single molecule array) and similar assays for detecting human BDNF in various sample types. The kit includes a bottle of capture beads, a bottle of detection reagent and standards.
Human BTC Ultrasensitive Antibody Pair Reference: RMH-BTC-96 Bead-conjugated antibody pair compatible with Simoa® (single molecule array) and similar assays for detecting human BTC in various sample types. The kit includes a bottle of capture beads, a bottle of detection reagent and standards.