Category: Antibodies

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  • Categories: Intracellular Functional Antibodies
  • Categories: Kits
Reference: HY-P9912A

Pertuzumab (PBS), a humanized monoclonal antibody, is a HER2 dimerization inhibitor for the treatment of metastatic HER2-positive breast cancer.

Reference: AT3003-100

NOTE: It is important to perform the click-reaction with Azide-x first, prior to antibody conjugation. UV illumination will damage the DBCO activity and thus antibody conjugation should only be performed after the click-reaction. Research Use Only Applications: Copper-free Click Chemistry oYo-Link® DBCO allows for the site-specific labeling of oYo-Link®-compatible antibodies with up to two dibenzocyclooctyne (DBCO) labels per antibody for subsequent copper-free click chemistry reactions. oYo-Link®-DBCO limits the attachment of the DBCO labels to the heavy chains of the antibody and therefore ensures that the DBCO label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 DBCO labels to be attached per antibody, providing precise antibody-conjugate ratios. The antibody labeling procedure simply requires mixing oYo-Link® -DBCO with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins (see Buffer Compatibility Table). Requirements: To label your compatible antibodies with oYo-Link®, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from the list here or purchase AlphaThera's LED Photo-Crosslinking Device Here. Purchasing Information: For Credit Card purchases, proceed with checkout on website. To Request a Quote email sales@alphathera.com. Technical Support: For questions concerning compatibility or click-chemistry procedure email support@alphathera.com

Reference: HY-P99676

Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer.

Reference: AT3003-500

NOTE: It is important to perform the click-reaction with Azide-x first, prior to antibody conjugation. UV illumination will damage the DBCO activity and thus antibody conjugation should only be performed after the click-reaction. Research Use Only Applications: Copper-free Click Chemistry oYo-Link® DBCO allows for the site-specific labeling of oYo-Link®-compatible antibodies with up to two dibenzocyclooctyne (DBCO) labels per antibody for subsequent copper-free click chemistry reactions. oYo-Link®-DBCO limits the attachment of the DBCO labels to the heavy chains of the antibody and therefore ensures that the DBCO label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 DBCO labels to be attached per antibody, providing precise antibody-conjugate ratios. The antibody labeling procedure simply requires mixing oYo-Link® -DBCO with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins (see Buffer Compatibility Table). Requirements: To label your compatible antibodies with oYo-Link®, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from the list here or purchase AlphaThera's LED Photo-Crosslinking Device Here. Purchasing Information: For Credit Card purchases, proceed with checkout on website. To Request a Quote email sales@alphathera.com. Technical Support: For questions concerning compatibility or click-chemistry procedure email support@alphathera.com

Reference: HY-P99004

(EC50=3 nM). hMC1R agonist 1 shows at least 300-fold selectivity for hMC1R over hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), and hMC5R (b>EC50=>1000 nM). hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family.

Reference: AT3003-1000

NOTE: It is important to perform the click-reaction with Azide-x first, prior to antibody conjugation. UV illumination will damage the DBCO activity and thus antibody conjugation should only be performed after the click-reaction. Research Use Only Applications: Copper-free Click Chemistry oYo-Link® DBCO allows for the site-specific labeling of oYo-Link®-compatible antibodies with up to two dibenzocyclooctyne (DBCO) labels per antibody for subsequent copper-free click chemistry reactions. oYo-Link®-DBCO limits the attachment of the DBCO labels to the heavy chains of the antibody and therefore ensures that the DBCO label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 DBCO labels to be attached per antibody, providing precise antibody-conjugate ratios. The antibody labeling procedure simply requires mixing oYo-Link® -DBCO with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins (see Buffer Compatibility Table). Requirements: To label your compatible antibodies with oYo-Link®, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from the list here or purchase AlphaThera's LED Photo-Crosslinking Device Here. Purchasing Information: For Credit Card purchases, proceed with checkout on website. To Request a Quote email sales@alphathera.com. Technical Support: For questions concerning compatibility or click-chemistry procedure email support@alphathera.com

Reference: HY-P99677

Izenivetmab (ZTS-00075623) is a caninized IgG2κ anti-NGFB monoclonal antibody.

Reference: AT3003-mIgG1-100

NOTE: It is important to perform the click-reaction with Azide-x first, prior to antibody conjugation. UV illumination will damage the DBCO activity and thus antibody conjugation should only be performed after the click-reaction. Research Use Only Applications: Copper-free Click Chemistry oYo-Link® DBCO allows for the site-specific labeling of oYo-Link®-compatible antibodies with up to two dibenzocyclooctyne (DBCO) labels per antibody for subsequent copper-free click chemistry reactions. oYo-Link®-DBCO limits the attachment of the DBCO labels to the heavy chains of the antibody and therefore ensures that the DBCO label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 DBCO labels to be attached per antibody, providing precise antibody-conjugate ratios. The antibody labeling procedure simply requires mixing oYo-Link® -DBCO with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins (see Buffer Compatibility Table). Requirements: To label your compatible antibodies with oYo-Link®, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from the list here or purchase AlphaThera's LED Photo-Crosslinking Device Here. Purchasing Information: For Credit Card purchases, proceed with checkout on website. To Request a Quote email sales@alphathera.com. Technical Support: For questions concerning compatibility or click-chemistry procedure email support@alphathera.com

Reference: HY-P99266

Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody targets CD4. Zanolimumab effectively inhibits T-cell receptor (TCR) signal transduction. Zanolimumab can be used for the research of heumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma.

Reference: AT3003-mIgG1-500

NOTE: It is important to perform the click-reaction with Azide-x first, prior to antibody conjugation. UV illumination will damage the DBCO activity and thus antibody conjugation should only be performed after the click-reaction. Research Use Only Applications: Copper-free Click Chemistry oYo-Link® DBCO allows for the site-specific labeling of oYo-Link®-compatible antibodies with up to two dibenzocyclooctyne (DBCO) labels per antibody for subsequent copper-free click chemistry reactions. oYo-Link®-DBCO limits the attachment of the DBCO labels to the heavy chains of the antibody and therefore ensures that the DBCO label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 DBCO labels to be attached per antibody, providing precise antibody-conjugate ratios. The antibody labeling procedure simply requires mixing oYo-Link® -DBCO with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins (see Buffer Compatibility Table). Requirements: To label your compatible antibodies with oYo-Link®, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from the list here or purchase AlphaThera's LED Photo-Crosslinking Device Here. Purchasing Information: For Credit Card purchases, proceed with checkout on website. To Request a Quote email sales@alphathera.com. Technical Support: For questions concerning compatibility or click-chemistry procedure email support@alphathera.com

Reference: HY-P99414

Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).

Reference: AT3001-100

Research Use Only Applications: Reactions with Thiol-reactive Groups oYo-Link® Thiol enables the site-specific labeling of oYo-Link®-compatible antibodies with a Thiol to the IgG heavy chain. oYo-Link® Thiol limits the attachment of the thiol labels to the heavy chains of the antibody and therefore ensures that the thiol label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 Thiol labels to be attached per antibody, providing precise antibody-conjugate ratios. The antibody labeling procedure simply requires mixing oYo-Link® Thiol with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried out in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins. (see Buffer Compatibility Table). Requirements: To label your compatible antibodies with oYo-Link®, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from our list or purchase AlphaThera's LED Photo-Crosslinking Device. Technical Support: For questions concerning compatibility or click-chemistry procedure email support@alphathera.com