Reagents

GLP-1R agonist 2 (compound 2) is a potent GLP-1R agonist. GLP-1R agonist 2 has the potential for the research of metabolic diseases like Type2 Diabetes and Obesity.

HO-PEG14-OH

Reference: HY-120430

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HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

TRPM8 antagonist 2

Reference: HY-112430

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TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.

MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

Reference: HY-132158

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MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC).

Ammonium sulphate,≥99.0%,AR-N152

Reference: HY-Y0261AS1

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Ammonium sulphate,≥99.0%,AR-15N2 is the deuterium labeled Ammonium sulphate,≥99.0%,AR[1]. Ammonium sulphate,≥99.0%,AR is an inorganic sulfate salt used for molecular biology[2].

α-Angelica lactone

Reference: HY-N0548

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α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic...

Atrasentan

Reference: HY-15403

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Atrasentan (ABT-627) is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA.

iNOS inhibitor-10

Reference: HY-152536

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iNOS inhibitor-10 is an iNOS inhibitor (IC50: 65 nM). iNOS inhibitor-10 has antiproliferative effect against triple negative breast cancer cells.

Chikusetsusaponin Iva

Reference: HY-N0818

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Chikusetsusaponin IVa a major active ingredient of triterpenoid saponins, exerts antithrombotic effects, including minor hemorrhagic events.

3-Chloro-L-tyrosine

Reference: HY-W041171

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3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

Rhodamine-N3 chloride

Reference: HY-D1269

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Rhodamine-N3 chloride is an azide-rhodamine fluorescent dye that can be used to label biomolecules containing alkyne groups.

Val-Cit-PAB-MMAF

Reference: HY-101909

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Val-Cit-PAB-MMAF is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAF contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin polymerization inhibitor MMAF (HY-15579)

ML141

Reference: HY-12755

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ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141...

PI3Kα-IN-6

Reference: HY-147767

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PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and...

Lithium 3,5-diiodosalicylate

Reference: HY-W250174

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Lithium 3,5-diiodosalicylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

(+)-Menthol

Reference: HY-W017277

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(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol can also...

Sodium stibogluconate

Reference: HY-100595

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Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL,...

UPF-523

Reference: HY-101311

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UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on...

Antioxidant agent-2

Reference: HY-145888

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Antioxidant agent-2 (comp 3c), an BBB-penetrated antioxidant agent and a selective metal ions chelator, presents good neuroprotective effect and hepatoprotective effect for the study of Alzheimer’s disease.

Lucidenic acid D

Reference: HY-107260

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Lucidenic acid D (Lucidenic acid D2) is a highly oxidized lanostane-type triterpenoid.

BTK-IN-14

Reference: HY-147584

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BTK-IN-14 is a potent inhibitor of BTK. BTK plays an important role in signaling mediated by B cell antigen receptor (BCR) and Fcγreceptor (FcγR) in B cells and myeloid cells, respectively. BTK-IN-14 has the potential...

DiSulfo-Cy5 alkyne

Reference: HY-151701

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DiSulfo-Cy5 alkyne is a fluorescent dye can be used as a click chemistry reagent.

Glyphosate-d2-1

Reference: HY-B0863S2

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Glyphosate-d2-1 is the deuterium labeled Glyphosate[1]. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate...

Dugesin C

Reference: HY-N11663

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Dugesin C is a diterpenoid isolated from the plant Salvia dugesii with a spiro carbocyclic ring system derived from the normal neocrotane skeleton.

PROTAC CDK9 ligand-1

Reference: HY-115729

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PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

Decanedioic acid-d4

Reference: HY-W014787S

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Decanedioic acid-d4 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA...

Ponatinib Acid

Reference: HY-135636

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Ponatinib Acid, an analogue of Ponatinib, is usually used as a labeled chemical or fluorescent probe.

N4-Benzoyl-2’-deoxy-5-iodocytidine

Reference: HY-154660

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N4-Benzoyl-2’-deoxy-5-iodocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on...

Thiolutin

Reference: HY-N6712

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Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM...

HA130

Reference: HY-19329

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HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

N3-PEG24-Hydrazide

Reference: HY-133321

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N3-PEG24-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Punicic acid

Reference: HY-139066

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Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and a ω-5 polyunsaturated fatty acid. Punicic acid has the potential for the research of various...

Bicalutamide

Reference: HY-14249

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Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer.

Methylisothiazolinone-d3 hydrochloride

Reference: HY-W010243S

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Methylisothiazolinone-d3 (hydrochloride) is the deuterium labeled Methylisothiazolinone (hydrochloride). Methylisothiazolinone hydrochloride is the constituent of the biocide Kathon CG. Methylisothiazolinone...

(E)-Methyl 4-coumarate

Reference: HY-N2492

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(E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate), found in several plants, such as Allium cepa or Morinda citrifolia L. leaves. (E)-Methyl 4-coumarate cooperates with Carnosic Acid in inducing apoptosis and killing...

Mal-PEG-Succinimidyl Valerate (MW 20000)

Reference: HY-140722

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Mal-PEG-Succinimidyl Valerate (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

DprE1-IN-1

Reference: HY-144341

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DprE1-IN-1 is a potent, orally active DprE1 inhibitor with favorable hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 displays potent?activity against both agent-susceptible and...

Methyl 10-methylundecanoate

Reference: HY-W127495

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Methyl 10-Methylundecanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Neolancerin

Reference: HY-N8088

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Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells.

Indacaterol-d3

Reference: HY-14299S

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Indacaterol-d3 is deuterium labeled Indacaterol.

Hispaglabridin A

Reference: HY-142099

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Hispaglabridin A is an antioxidant that is effective at inhibiting lipid peroxidation.

m-PEG6-CH2CH2COOH

Reference: HY-W040239

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m-PEG6-CH2CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.

Antibacterial agent 111

Reference: HY-147878

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Antibacterial agent 111 (Compound 3) is an antibacterial agent with MIC values of 3.90 μg/mL and 0.49 μg/mL against B. cereus and K. pneumonia, respectively. Antibacterial agent 111 firmly binds with tyrosyl-tRNA...

Meclofenoxate hydrochloride

Reference: HY-17555

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Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.

FAAH/MAGL-IN-3

Reference: HY-146342

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FAAH/MAGL-IN-3 (Compound 10) is an irreversible fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) dual inhibitor with IC50 values of 179 and 759 nM against FAAH and MAGL, respectively....

ABL127

Reference: HY-108317

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ABL127 is a selective and covalent inhibitor of protein methylesterase 1 (PME-1) with IC50s of 6.4 nM and 4.2 nM in HEK293T and MDA-MB-231 cells, respectively.

Quercetin

Reference: HY-18085

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Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

(+)-Tetrabenazine

Reference: HY-B0590B

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(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by...

E7090

Reference: HY-101466

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E7090 is an orally available, potent, and selective FGFR inhibitor with IC50s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4, respectively.

Methyl aminolevulinate

Reference: HY-A0169

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Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT). Methyl aminolevulinate is a proagent that can be metabolized to Protoporphyrin IX.

BI-2081

Reference: HY-148247

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BI-2081 is a GPR40 (FFAR1) partial agonist (EC50: 4 nM). BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in...

3’-β-Amino-2’,3’-dideoxy-5’-O-methoxy trityluridine

Reference: HY-154437

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3’-β-Amino-2’,3’-dideoxy-5’-O-methoxy trityluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this...

LeuRS-IN-1 hydrochloride

Reference: HY-139987A

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LeuRS-IN-1 hydrochloride is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 hydrochloride has IC50 and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively....

RI-962

Reference: HY-148382

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RI-962 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor. RI-962 inhibits RIPK1 with an IC50 value of 35.0 nM. RI-962 can be used for the research of nervous system diseases and...

S (+) Tolperisone-d10

Reference: HY-143800S

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S (+) Tolperisone-d10 is the deuterium labeled S (+) Tolperisone[1].

Guanfu base I

Reference: HY-N5004

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Guanfu base I (Acorine) is an active metabolite of Guanfu base A, isolated from Aconitum coreanum, and has a potent anti-arrhythmic effect.

Bekanamycin

Reference: HY-B1174

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Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain.

Dyrk1A/B-IN-1

Reference: HY-146337

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Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable DYRK1A and DYRK1B inhibitor with Kis of 67.8 nM and 237.9 nM, and IC50s of 1.1 μM and 0.8 μM, respectively. Dyrk1A/B-IN-1 is not toxic to human...

3CPLro-IN-1

Reference: HY-144260

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3CPLro-IN-1 (compound A17) is a potent and orally active inhibitor of SARS-CoV-2 3CLpro with an IC50 of 5.65 μM. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and...

(S)-Purvalanol B

Reference: HY-18299B

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(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.

Staurosporine (GMP)

Reference: HY-15141G

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Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent,...

Fosmidomycin sodium salt

Reference: HY-112853

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Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.

Cantrixil

Reference: HY-114250

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Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian...

7-α-Methylthio Spironolactone-d3

Reference: HY-13284S

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7-α-Methylthio Spironolactone-d3 is the deuterium labeled 7-α-Methylthio Spironolactone[1].

Dimethylmalonic acid

Reference: HY-W007894

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Dimethylmalonic acid is a short-chain dicarboxylic acid in human serum. Dimethylmalonic acid is also a volatile organic compound detected in alveolar breath.

AE-3763

Reference: HY-19406

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AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.

DL-Asparagine

Reference: HY-W017442

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DL-Asparagine is a racemic melange of the Aparagine L and D-enantiomers. DL-Asparagine has been used in growth-media for bacteria-growth.

γ-Tocopherol

Reference: HY-N7148

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γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses...

EGFR/CSC-IN-1

Reference: HY-132883

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EGFR/CSC-IN-1 is a potential EGFR (IC50 10.52 nM) and cancer stem cell (CSC) dual inhibitor for triple-negative breast cancer research.

DCEBIO

Reference: HY-102052

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DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane...

23-Epi-26-deoxycimicifugoside

Reference: HY-N11070

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23-Epi-26-deoxycimicifugoside ia a triterpene xyloside that can be isolated from Cimicifuga racemosa.

KN-93 hydrochloride

Reference: HY-15465A

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KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.

Afatinib D6

Reference: HY-10261S

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Afatinib-d6 is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor[1].

Ellipyrone A

Reference: HY-N10360

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Ellipyrone A, a γ-pyrone enclosed macrocyclic poyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC50=0.35 mM). Ellipyrone A also has anti-carbolytic property against α-glucosidase (IC50=0.74 mM)...

Fulvestrant-9-sulfone-d3

Reference: HY-146485S

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Fulvestrant-9-sulfone-d3 is the deuterium labeled Fulvestrant-9-sulfone[1].

Ozagrel

Reference: HY-B0428

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Ozagrel (OKY-046)is an anti-asthmatic agent and a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel is an antiplatelet agent, which selectively inhibits human platelet aggregation with an IC50 of 53.12 μM.

Biotin-11-dUTP trisodium

Reference: HY-D1029A

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Biotin-11-dUTP trisodium is a fluorescent substitute for dTTP.

Buparlisib

Reference: HY-70063

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Buparlisib (BKM120; NVP-BKM120) is a pan-class I PI3K inhibitor, with IC50s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively.

hCAII-IN-8

Reference: HY-152140

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hCAII-IN-8, an amide, is a highly selective carbonic anhydrase (CA) inhibitor with an IC50 value of 0.18 μM against hCA II.

t-Boc-aminocaproicnitrilotriacetic acid

Reference: HY-W127828

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t-Boc-aminocaproicnitrilotriacetic Acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Euphoheliosnoid A

Reference: HY-N11662

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Euphoheliosnoid A (Compound 24) is a diterpenoid that can significantly enhance the killing activity of natural killer (NK) cells towards H1299-luci cells and A549-luci cells at the concentration of 2.5 μM.

Wnt/β-catenin agonist 2

Reference: HY-141873

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Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction. (From patent WO2007078113A1,...

NPEC-caged-(S)-AMPA

Reference: HY-103235

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NPEC- caged-(S)-AMPA, a caged neurotransmitter analog, is a NPEC photoprotecting group caged the (S)-AMPA (HY-100815A) to make caged ligands specific for glutamate receptor sub-types. NPEC- caged-(S)-AMPA selectively...

Amino-PEG4-CH2COOH

Reference: HY-130524

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Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

PT2399

Reference: HY-108697

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PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo.

Allotetrahydrocortisol-d5

Reference: HY-113215S

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Allotetrahydrocortisol-d5 is the deuterium labeled Allotetrahydrocortisol. Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in...

Potassium cyanate-13c

Reference: HY-Y1352S

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Potassium cyanate-13C is the 13C labeled Potassium cyanate[1].

PKR activator 1

Reference: HY-135883

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PKR activator 1 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035865A1, compound E7-93.

CB2 receptor antagonist 1

Reference: HY-147707

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Hexyl resorcinol derivative 29 has been proved to be a CB2 selective competitive antagonist / reverse agonist with good potency. Olivanol and 5- (2-methyloctane-2-yl) resorcinol derivatives 23 and 24 showed...

alpha-Hederin

Reference: HY-N0255

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alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce...

Enitociclib

Reference: HY-103019

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Enitociclib ((+)-Enitociclib) is an enanthiomer of BAY-1251152 with rotation (+). Enitociclib is a potent and selective CDK9 inhibitor with an IC50 of 3 nM. Enitociclib has anti-tumour activity.

Thalidomide 4-fluoride

Reference: HY-41547

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Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein...

PROTAC BRD4 Degrader-2

Reference: HY-133136

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PROTAC BRD4 Degrader-2 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 14.2 nM against BRD4 BD1.

Calcium carboxymethyl cellulose

Reference: HY-154704

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Calcium carboxymethyl cellulose can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical...

Category: Reagents

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