Hymeglusin Reference: 11899-2,5 A fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme; targets cell walls of pathogens such as S. aureus in a mouse sepsis model of infection
Eplerenone-d3 Reference: 31610-2,5 An internal standard for the quantification of eplerenone by GC- or LC-MS
(–)-Chaetominine Reference: 13135-2,5 A cytotoxic alkaloid; inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively); induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing cytochrome C release, and activation of caspase-3 and caspase-9; decreases MRP1-mediated doxorubicin efflux and restores sensitivity to doxorubicin in resistant K562 cells
Cyclopentenone Prostaglandin HPLC Mixture Reference: 10000-1 This mixture contains all of the major UV-absorbing cyclopentenone prostaglandins and their precursors. Contents:,100 µg of each compound, Prostaglandin A2 (Item No. 10210),Prostaglandin B2 (Item No. 11210) ,Prostaglandin D2 (Item No. 12010) ,Prostaglandin E2 (Item No. 14010),Prostaglandin J2 (Item No. 18500),15-deoxy-Δ12,14-Prostaglandin J2 (Item No. 18570)
S-(5'-Adenosyl)-L-methionine chloride (hydrochloride) Reference: 13956-2,5 A ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases
Vasoactive Eicosanoid HPLC Mixture Reference: 10003-1 This mixture contains the characteristic metabolites of both PGI2 and TXA2. Contents: Thromboxane B2, 11-dehydro Thromboxane B2, 6-keto Prostaglandin F1α, 2,3-dinor-6-keto Prostaglandin F1α (100 µg each), and 12(S)-HHTrE (5 µg).
Ikarugamycin Reference: 15386-2,5 A macrocyclic antibiotic that exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells); 1-4 μM inhibits oxidized LDL-induced accumulation of cholesteryl esters in macrophages; inhibits clathrin-coated pit-mediated endocytosis
p-Cymene Reference: 23159-100 A monoterpene with diverse biological activities; inhibits the growth of S. typhimurium, E. coli, L. monocytogenes, S. epidermidis, and S. aureus (MICs = 0.266-0.608% v/v); decreases the invasive activity of HT-1080 human fibrosarcoma cells in vitro by 87% at 600 µM; in mouse hippocampus, reduces lipid peroxidation and nitrite content by 65.5 and 71.2%, respectively, and increases SOD and catalase activities by 22.7 and 119.3%, respectively, compared to vehicle control animals, at 50 mg/kg
4-oxo-2-Nonenal-d3 Reference: 10004174-1 4-ONE-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE by GC- or LC-MS.
Cercosporamide Reference: 15500-2,5 A natural antifungal phytotoxin that selectively and potently inhibits fungal Pkc1, which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1); potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells
(−)-Isopulegol Reference: 23161-100 A monoterpene with diverse biological activities; antibacterial activity against S. aureus, E. faecium, E. coli, and M. smegmatis (MICs = 0.78, 12.5, 0.78, and 1.56 μl/ml, respectively, in an agar diffusion assay) and antifungal activity against C. albicans and A. niger (MIC = 1.56 μl/ml for both in an agar diffusion assay); inhibits C. albicans morphogenesis, adhesion, and biofilm formation (MICs = 0.125, 4, and 0.25 mg/ml, respectively); increases immobility time in the forced swim and tail suspension tests and increases the number of head dips in a hole board test and time spent in the open arms of the elevated plus maze in mice at 50 mg/kg; reduces the size of ulcerated lesions in the stomach in mouse models of ethanol- and indomethacin-induced gastric lesions at 100 mg/kg,
4-oxo-2-Nonenal-d3 Reference: 10004174-100 4-ONE-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE by GC- or LC-MS.