Reagents (3)

Azido-PEG16-Boc

Reference: HY-140784

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Azido-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

KRAS G12C inhibitor 29

Reference: HY-142478

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KRAS G12C inhibitor 29 is a KRAS G12C inhibitor extracted from patent WO2021252339A1, compound 3. KRAS G12C inhibitor 29 can be used for the research of cancer.

p-Toluic acid-d4 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted?benzoic acid?and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid...

4′,5′-Didehydro-5′-deoxyadenosine

Reference: HY-154232

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4′,5′-Didehydro-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on...

(±)-β-Methylphenethylamine-d9

Reference: HY-W213592S

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(±)-β-Methylphenethylamine-d9 is the deuterium labeled (±)-β-Methylphenethylamine[1].

Niraparib tosylate hydrate

Reference: HY-10619E

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Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA...

Cjoc42

Reference: HY-138054

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Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin....

Ekersenin

Reference: HY-N11509

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Ekersenin is a natural product that can be isolated from Ekererbegia senegalensis.

Doxycycline (hyclate)

Reference: HY-N0565B

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Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity.

Ergothioneine

Reference: HY-N1914

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Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant.

20-Deoxocarnosol

Reference: HY-122944

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20-Deoxocarnosol (compound 7) is a potent anti-cancer agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells.

TC-E 5008

Reference: HY-110144

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TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E...

Necrostatin 2 racemate

Reference: HY-14622A

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Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect.

A1/A3 AR antagonist 2

Reference: HY-146479

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The compound is an a1/a3 adenosine receptor antagonist, which helps to research (neurological) inflammatory diseases.

Mal-PEG4-C2-NH2 TFA

Reference: HY-138380

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Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Acemetacin

Reference: HY-B0482

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Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

Cadazolid

Reference: HY-100436

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Cadazolid (ACT-179811) is a new oxazolidinone antibiotic with potent activity against Clostridium difficile.

Naftopidil-d5

Reference: HY-B0391S1

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Naftopidil-d5 is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes,...

BI-4020

Reference: HY-129550

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BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines) but also the...

MRTX-1257

Reference: HY-114436

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MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.

Amlodipine

Reference: HY-B0317

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Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium....

THR-β agonist 3

Reference: HY-143614

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THR-β agonist 3 is a potent agonist of THR-β. THR-β agonist 3 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as...

(S)-2-acetamido-4-amino-4-oxobutanoic acid

Reference: HY-W016798

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(S)-2-acetamido-4-amino-4-oxobutanoic acid is an endogenous metabolite.

Lp-PLA2-IN-5

Reference: HY-142670

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Lp-PLA2-IN-5 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in...

SARS-CoV-2 nsp3-IN-1

Reference: HY-150062

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SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC50 value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1...

Vitamin B5-13C3,15N hemicalcium hemihydrate

Reference: HY-144432S

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Vitamin B5-13C3,15N (hemicalcium hemihydrate) is the deuterium labeled Vitamin B5 (hemicalcium hemihydrate)[1].

4-Hydroxybenzylamine

Reference: HY-W004078

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4-Hydroxybenzylamine is an endogenous metabolite.

COX-2-IN-28

Reference: HY-150553

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COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively.

Biotin-PEG2-acid

Reference: HY-126958

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Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Fmoc-NH-PEG9-CH2CH2COOH

Reference: HY-130167

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Fmoc-NH-PEG9-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG9-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

2',3',5'-Tri-O-acetyl-2-thiouridine

Reference: HY-154170

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2',3',5'-Tri-O-acetyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on...

Mal-Phe-C4-Val-Cit-PAB-DMEA

Reference: HY-126674

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Mal-Phe-C4-Val-Cit-PAB-DMEA is a cleavable ADC linker containing a Maleimide group. Mal-Phe-C4-Val-Cit-PAB-DMEA is used for making antibody-drug conjugate.

Sucistil

Reference: HY-145614

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Sucistil is an active compound. hemoglobin sucistil (bovine) is an oxygen carrier.

CDK7-IN-6

Reference: HY-145394

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CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC50≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5....

Amycolatopsin A

Reference: HY-N11048

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Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG)...

(-)-Corey lactone diol

Reference: HY-W008393

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(-)-Corey lactone diol is a reduced version of corey aldehyde. A building block in the chemical synthesis.

Dodecanoate-d2 potassium

Reference: HY-W115763S

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Dodecanoate-d2 (potassium) is the deuterium labeled Dodecanoate[1].

Dansylcadaverine

Reference: HY-D1027

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Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated...

Proglumide sodium

Reference: HY-103354

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Proglumide sodium is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide sodium selective blocks CCK’s effects in the central nervous system (CNS). Proglumide sodium has ability...

Antitubercular agent 34

Reference: HY-151957

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Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of MtbH37Rv with a MIC90 value of 1.25 μg/mL with the ability of escaping metabolic degradation by human...

RG3039

Reference: HY-102020

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RG3039 (PF-06687859) is an orally bioavailable and brain-penetrant DcpS inhibitor with an IC50 of 0.069 nM.

6-Methylnicotinamide

Reference: HY-W015815

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6-Methylnicotinamide, a derivate of nicotinamide, is an endogenous metabolite. A sudden increase of 6-methylnicotinamide in the acute stages of intracerebral hemorrhage (ICH) exacerbates neurological damages.

Ambroxide

Reference: HY-N1384

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Ambroxide is a naturally occurring terpenoid. Ambroxide is one of the key constituents of ambergris.

12:0 EPC chloride

Reference: HY-144017

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12:0 EPC chloride is a cationic phospholipid. 12:0 EPC chloride can be used for drug delivery.

ALV1

Reference: HY-145776

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ALV1 potently induces degradation of both Ikaros and Helios without unexpected off-target activity. ALV1 binds CRBN with IC50 of 0.55 µM. ALV1 degrades cells stably expressing IKZF1Δ and IKZF2Δ GFP fusions with...

Clevidipine-d7

Reference: HY-17436S1

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Clevidipine-d7 is the deuterium labeled Clevidipine. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative...

Ethyl undecanoate

Reference: HY-W014207

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Ethyl undecanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Butyl Palmitate

Reference: HY-W127338

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Butyl Palmitate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Temocaprilat

Reference: HY-A0117

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Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE). Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has...

Simvastatin acid calcium hydrate

Reference: HY-119695B

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Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human...

(Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5

Reference: HY-143699S

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(Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5 is the deuterium labeled (Rac)-1,2-Bis-palmitol-3-chloropropanediol[1].

6-Amino-5-azacytidine

Reference: HY-111643

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6-Amino-5-azacytidine inhibits the growth of bacteria E. coli.

FCCP

Reference: HY-100410

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FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.

Penicillin G-d7 potassium salt

Reference: HY-N7139S1

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Penicillin G-d7 (potassium) is the deuterium labeled Penicillin G potassium salt[1].

Casanthranol

Reference: HY-B2134

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Casanthranol is a concentrated mixture of anthranol glycosides from cascara sagrada (dried bark of Rhamnus p.) and used as a laxative in constipation and various medical conditions, stimulant laxative Casanthranol...

(±)-Hexanoylcarnitine chloride

Reference: HY-100978

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(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker...

Aficamten

Reference: HY-139465

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Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM).

Glycylglycine

Reference: HY-D0889

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Glycylglycine is the simplest of all peptides and could function as a gamma-glutamyl acceptor.

Mifepristone-13C,d3

Reference: HY-13683S1

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Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

AMG 579

Reference: HY-12913

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AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.

Imidacloprid-urea

Reference: HY-131964

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Imidacloprid-urea is a metabolite of Imidacloprid. Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Imidacloprid-urea can occupy or block...

(E)-4-Oxo-2-nonenal

Reference: HY-114524

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(E)-4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides....

EP4 receptor antagonist 1

Reference: HY-133123

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EP4 receptor antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist for cancer immunotherapy. EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM...

5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine

Reference: HY-154779

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5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this...

Methylkushenol C

Reference: HY-N10787

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Methylkushenol C is a phenolic substance. Methylkushenol C can be isolated from Sophora flavescens.

D-Glucose-d1-2

Reference: HY-B0389S4

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D-Glucose-d-22 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general...

1-O-Acetyl-6beta-O-Isobutyrylbritannilactone

Reference: HY-N10847

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1-O-Acetyl-6beta-O-Isobutyrylbritannilactone (compound 5), a sesquiterpene lactone, can be isolated from the flowers of Inula britannica. 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone shows significant cytotoxicity to...

PROTAC BRD4 Degrader-1

Reference: HY-133131

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PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression.

Notoginsenoside Fe

Reference: HY-N0046

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Notoginsenoside Fe is a natural compound isolated from Panax pseudo-ginseng.

Geraniol

Reference: HY-N6952

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Geraniol, an olefinic terpene, was found to inhibit growth of Candida albicans and Saccharomyces cerevisiae strains.

Xylose-3-13C

Reference: HY-N0537S5

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Xylose-3-13C is the 13C labeled Xylose.

Scopoletin acetate

Reference: HY-N1254

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Scopoletin acetate is a coumarin isolated from Artemisia granatensis.

Eravacycline

Reference: HY-16980

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Eravacycline is a potent and broad-spectrum antibacterial agent.

SD 0006

Reference: HY-11087

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SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α.

Fingolimod Mono-lactate-d4 hydrochloride

Reference: HY-143959S

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Fingolimod Mono-lactate-d4 (hydrochloride) is the deuterium labeled Fingolimod Mono-lactate hydrochloride[1].

GaTx2

Reference: HY-P1105

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GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in...

Estradiol-d3

Reference: HY-B0141S

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Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through...

Tortoside A

Reference: HY-N8154

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Tortoside A is a bioactive compound that could be found in the roots of Ilex pubescens.

Photosensitizer-2

Reference: HY-147690

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Photosensitizer-2 (compound 1) is a organic D-π-A sensitizer against phototoxicity. Photosensitizer-2 contains an acrylic acid moiety that exerts high levels of phototoxicity. Photosensitizer-2 shows antitumor...

Ezetimibe phenoxy glucuronide

Reference: HY-135391

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Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor.

Nabumetone

Reference: HY-B0559

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Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.

Vanillylmandelic acid-d1

Reference: HY-113121S1

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Vanillylmandelic acid-d is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the...

(Asp37)-Amyloid β-Protein (1-42)

Reference: HY-P4391

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(Asp37)-Amyloid β-Protein (1-42) is the G37D mutant of wild-type Amyloid-beta (1-42) peptide.

LY 254155

Reference: HY-14523

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LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.

CAPS

Reference: HY-D0869

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CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis.

L-Leucine-d1

Reference: HY-N0486S11

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L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

D-Allose

Reference: HY-128741

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D-Allose is an endogenous metabolite.

14-Deoxy-11,12-didehydroandrographolide

Reference: HY-N1490

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14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation.

Carboxy primaquine-d4

Reference: HY-142842S

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Carboxy primaquine-d4 is the deuterium labeled Carboxy primaquine[1].

FASN-IN-4 tosylate

Reference: HY-12648A

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FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM.

LpxH-IN-AZ1

Reference: HY-130836

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LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .

m-PEG12-acid

Reference: HY-135820

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m-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Griseoluteic acid

Reference: HY-118651

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Griseoluteic acid, a phenazine antibiotic, is originally isolated from S. griseoluteus. Griseoluteic acid is a breakdown product of griseolutein A and B.

APJ receptor agonist 3

Reference: HY-139876

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APJ receptor agonist 3 is a potent and orally active APJ receptor agonist with an EC50 value of 0.027 nM.

Cyclopropyl-1 Methyl-Ketone-d4

Reference: HY-Y0226S

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Cyclopropyl-1 Methyl-Ketone-d4 is the deuterium labeled Cyclopropyl methyl ketone[1].

Cholesteryl palmitate-d9

Reference: HY-W010708S

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Cholesteryl palmitate-d9 is the deuterium labeled Cholesteryl palmitate. Cholesteryl palmitate is a useful prognostic biomarker for chronic interstitial pneumonia (CIP).

endo-BCN-PEG2-NH2

Reference: HY-W072752

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endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

diABZI STING agonist-1 (Tautomerism)

Reference: HY-112921

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diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

HBV-IN-17

Reference: HY-144320

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HBV-IN-17 (compound 8) is a potent HBV capsid assembly modulator with an EC50 of 511 nM.

A2ti-2

Reference: HY-136466

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A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2...

Category: Reagents

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