UPF-523 Reference: HY-101311 UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis.
Antioxidant agent-2 Reference: HY-145888 Antioxidant agent-2 (comp 3c), an BBB-penetrated antioxidant agent and a selective metal ions chelator, presents good neuroprotective effect and hepatoprotective effect for the study of Alzheimer’s disease.
Lucidenic acid D Reference: HY-107260 Lucidenic acid D (Lucidenic acid D2) is a highly oxidized lanostane-type triterpenoid.
BTK-IN-14 Reference: HY-147584 BTK-IN-14 is a potent inhibitor of BTK. BTK plays an important role in signaling mediated by B cell antigen receptor (BCR) and Fcγreceptor (FcγR) in B cells and myeloid cells, respectively. BTK-IN-14 has the potential for the research of related diseases, especially autoimmune diseases, inflammatory diseases or cancer (extracted from patent WO2022057894A1, compound 1).
DiSulfo-Cy5 alkyne Reference: HY-151701 DiSulfo-Cy5 alkyne is a fluorescent dye can be used as a click chemistry reagent.
Glyphosate-d2-1 Reference: HY-B0863S2 Glyphosate-d2-1 is the deuterium labeled Glyphosate[1]. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[2].
Dugesin C Reference: HY-N11663 Dugesin C is a diterpenoid isolated from the plant Salvia dugesii with a spiro carbocyclic ring system derived from the normal neocrotane skeleton.
PROTAC CDK9 ligand-1 Reference: HY-115729 PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
Decanedioic acid-d4 Reference: HY-W014787S Decanedioic acid-d4 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].
Ponatinib Acid Reference: HY-135636 Ponatinib Acid, an analogue of Ponatinib, is usually used as a labeled chemical or fluorescent probe.
N4-Benzoyl-2’-deoxy-5-iodocytidine Reference: HY-154660 N4-Benzoyl-2’-deoxy-5-iodocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
Thiolutin Reference: HY-N6712 Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation.