Reagents (3)

3CPLro-IN-1

Reference: HY-144260

€0.00 (tax incl.)

3CPLro-IN-1 (compound A17) is a potent and orally active inhibitor of SARS-CoV-2 3CLpro with an IC50 of 5.65 μM. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and...

(S)-Purvalanol B

Reference: HY-18299B

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(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.

Staurosporine (GMP)

Reference: HY-15141G

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Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent,...

Fosmidomycin sodium salt

Reference: HY-112853

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Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.

Cantrixil

Reference: HY-114250

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Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian...

7-α-Methylthio Spironolactone-d3

Reference: HY-13284S

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7-α-Methylthio Spironolactone-d3 is the deuterium labeled 7-α-Methylthio Spironolactone[1].

Dimethylmalonic acid

Reference: HY-W007894

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Dimethylmalonic acid is a short-chain dicarboxylic acid in human serum. Dimethylmalonic acid is also a volatile organic compound detected in alveolar breath.

AE-3763

Reference: HY-19406

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AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.

DL-Asparagine

Reference: HY-W017442

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DL-Asparagine is a racemic melange of the Aparagine L and D-enantiomers. DL-Asparagine has been used in growth-media for bacteria-growth.

γ-Tocopherol

Reference: HY-N7148

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γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses...

EGFR/CSC-IN-1

Reference: HY-132883

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EGFR/CSC-IN-1 is a potential EGFR (IC50 10.52 nM) and cancer stem cell (CSC) dual inhibitor for triple-negative breast cancer research.

DCEBIO

Reference: HY-102052

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DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane...

23-Epi-26-deoxycimicifugoside

Reference: HY-N11070

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23-Epi-26-deoxycimicifugoside ia a triterpene xyloside that can be isolated from Cimicifuga racemosa.

KN-93 hydrochloride

Reference: HY-15465A

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KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.

Afatinib D6

Reference: HY-10261S

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Afatinib-d6 is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor[1].

Ellipyrone A

Reference: HY-N10360

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Ellipyrone A, a γ-pyrone enclosed macrocyclic poyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC50=0.35 mM). Ellipyrone A also has anti-carbolytic property against α-glucosidase (IC50=0.74 mM)...

Fulvestrant-9-sulfone-d3

Reference: HY-146485S

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Fulvestrant-9-sulfone-d3 is the deuterium labeled Fulvestrant-9-sulfone[1].

Ozagrel

Reference: HY-B0428

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Ozagrel (OKY-046)is an anti-asthmatic agent and a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel is an antiplatelet agent, which selectively inhibits human platelet aggregation with an IC50 of 53.12 μM.

Biotin-11-dUTP trisodium

Reference: HY-D1029A

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Biotin-11-dUTP trisodium is a fluorescent substitute for dTTP.

Buparlisib

Reference: HY-70063

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Buparlisib (BKM120; NVP-BKM120) is a pan-class I PI3K inhibitor, with IC50s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively.

hCAII-IN-8

Reference: HY-152140

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hCAII-IN-8, an amide, is a highly selective carbonic anhydrase (CA) inhibitor with an IC50 value of 0.18 μM against hCA II.

t-Boc-aminocaproicnitrilotriacetic acid

Reference: HY-W127828

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t-Boc-aminocaproicnitrilotriacetic Acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Euphoheliosnoid A

Reference: HY-N11662

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Euphoheliosnoid A (Compound 24) is a diterpenoid that can significantly enhance the killing activity of natural killer (NK) cells towards H1299-luci cells and A549-luci cells at the concentration of 2.5 μM.

Wnt/β-catenin agonist 2

Reference: HY-141873

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Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction. (From patent WO2007078113A1,...

NPEC-caged-(S)-AMPA

Reference: HY-103235

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NPEC- caged-(S)-AMPA, a caged neurotransmitter analog, is a NPEC photoprotecting group caged the (S)-AMPA (HY-100815A) to make caged ligands specific for glutamate receptor sub-types. NPEC- caged-(S)-AMPA selectively...

Amino-PEG4-CH2COOH

Reference: HY-130524

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Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

PT2399

Reference: HY-108697

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PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo.

Allotetrahydrocortisol-d5

Reference: HY-113215S

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Allotetrahydrocortisol-d5 is the deuterium labeled Allotetrahydrocortisol. Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in...

Potassium cyanate-13c

Reference: HY-Y1352S

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Potassium cyanate-13C is the 13C labeled Potassium cyanate[1].

PKR activator 1

Reference: HY-135883

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PKR activator 1 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035865A1, compound E7-93.

CB2 receptor antagonist 1

Reference: HY-147707

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Hexyl resorcinol derivative 29 has been proved to be a CB2 selective competitive antagonist / reverse agonist with good potency. Olivanol and 5- (2-methyloctane-2-yl) resorcinol derivatives 23 and 24 showed...

alpha-Hederin

Reference: HY-N0255

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alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce...

Enitociclib

Reference: HY-103019

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Enitociclib ((+)-Enitociclib) is an enanthiomer of BAY-1251152 with rotation (+). Enitociclib is a potent and selective CDK9 inhibitor with an IC50 of 3 nM. Enitociclib has anti-tumour activity.

Thalidomide 4-fluoride

Reference: HY-41547

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Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein...

PROTAC BRD4 Degrader-2

Reference: HY-133136

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PROTAC BRD4 Degrader-2 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 14.2 nM against BRD4 BD1.

Calcium carboxymethyl cellulose

Reference: HY-154704

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Calcium carboxymethyl cellulose can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical...

7-O-Methyl Ivermectin B1a

Reference: HY-147002

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7-O-Methyl Ivermectin B1a is an analogue of Ivermectin B1a (HY-126937).

PKM2 activator 2

Reference: HY-147368

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PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal...

Sarcophine

Reference: HY-124550

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Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC50 value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum.

PDEC-NB

Reference: HY-126498

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PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate?(ADC).

2’,3’-Bis(O-t-butyldimethylsilyl)-2-thiouridine

Reference: HY-154417

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2’,3’-Bis(O-t-butyldimethylsilyl)-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process...

GSK461364

Reference: HY-50877

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GSK461364 is a selective, reversible and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with a Ki value of 2.2 nM.

DC-LC3in-D5

Reference: HY-141882

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DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or...

Tebipenem pivoxil

Reference: HY-B0396

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Tebipenem pivoxil (L084) is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis.

1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one

Reference: HY-N10158

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1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (compound 39), a diarylheptanoid, exhibits antiproliferative activity towards human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells.

ZL-Pin13

Reference: HY-143903

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ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the...

Clomipramine-13C,d3 hydrochloride

Reference: HY-B0457S2

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Clomipramine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM....

α,β-Trehalose

Reference: HY-W145656

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α,β-Trehalose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

14-Demethyl-lanosterol-d6

Reference: HY-146777S

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14-Demethyl-lanosterol-d6 is deuterium labeled 14-Demethyl-lanosterol.

Lenalidomide-C5-NH2 hydrochloride

Reference: HY-122725B

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Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as...

Eldecalcitol-d6

Reference: HY-A0020S

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Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis.

Acetic acid magnesium tetrahydrate

Reference: HY-Y0319G

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Acetic acid magnesium tetrahydrate is a hydrated form of anhydrous magnesium acetate salt. As a salt form of Magnesium, Magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble...

Coenzyme Q10-d9

Reference: HY-N0111S2

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Coenzyme Q10-d9 is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

Britannilactone diacetate

Reference: HY-N4190

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Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial...

EB-0156

Reference: HY-145274

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EB-0156 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC50s of 0.0479 and less than 0.001 μM, respectively. EB-0156 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0156...

Doxorubicin-13C,d3 TFA

Reference: HY-15142AS1

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Doxorubicin-13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicin. Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase...

Hydroxy naphthol blue disodium

Reference: HY-W151206

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Hydroxy naphthol blue disodium, an azo dye, is a metal indicator for calcium and a colorimetric reagent for alkaline earth metal ions ( λmax = 650 nm). In the pH range between 12 and 13, the solution of the indicator...

HS56

Reference: HY-123983

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HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction....

Acoramidis hydrochloride

Reference: HY-109165A

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Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis.

(S)-GNE-140

Reference: HY-100742B

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(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

SC 34301

Reference: HY-105052

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SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice.

(S)-(-)-Bay-K-8644

Reference: HY-15124

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(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).

CC-17369

Reference: HY-123215

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CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for...

D-Glucose-13C-4

Reference: HY-B0389S16

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D-Glucose-13C-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism,...

Antitubercular agent-10

Reference: HY-132928

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Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.

Imiclopazine

Reference: HY-137088

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Imiclopazine is a phenothiazine derivative with with psychomotor stabilizing properties, antiaggressive and antiemetic effects.

11,12-De(methylenedioxy)danuphylline

Reference: HY-N1013

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11,12-De(methylenedioxy)danuphylline is an indole alkaloid compound isolated from the leaves and stems of Kopsia officinalis.

Methyl propionate-PEG12

Reference: HY-130186

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Methyl propionate-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

DRB18

Reference: HY-145963

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DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and...

SJM-3

Reference: HY-131941

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SJM-3 is a positive allosteric modulator of different isoforms of the GABAA receptor. SJM-3 binds at the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.

LC kinetic stabilizer-2

Reference: HY-145890

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LC kinetic stabilizer-2 is a potent amyloidogenic immunoglobulin light chain (LC) kinetic stabilizer with an EC50 of 24 nM.

SARS-CoV-2-IN-23 disodium

Reference: HY-151269A

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SARS-CoV-2-IN-23 disodium is a two-armed diphosphate ester and medium length molecular tweezers. SARS-CoV-2-IN-23 disodium exhibits antiviral activity with IC50s of 8.2 μM and 2.6 μM against SARS-CoV-2 activity and...

Sodium dodecyl sulfate for molecular biology

Reference: HY-Y0316C

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Sodium dodecyl sulfate,for molecular biology,≥98.5% is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Methotrexate α-tert-butyl ester

Reference: HY-133887

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Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and...

5-Oxoprolyltryptophan

Reference: HY-118570

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5-Oxoprolyltryptophan is a model substrate for investigating the increase of serotonin at the cerebral level.

Belinostat

Reference: HY-10225

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Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.

Enniatin complex

Reference: HY-N6706

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Enniatin complex is a mixture of cyclohexadepsipeptides isolated largely from Fusarium species of fungi, and has ionophoric, antibiotic, and in vitro hypolipidaemic properties. Enniatin complex inhibits enzymes like...

Brilliant blue G-250

Reference: HY-D0014

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Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation. In the Bradford protein assay, protein concentrations...

20S Proteasome-IN-2

Reference: HY-150590

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20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC50 of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in...

2-Azidoethyl β-D-glucopyranoside

Reference: HY-W145563

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2-Azidoethyl β-D-Glucopyranoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

INCB38579

Reference: HY-101188

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INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and...

SMO-IN-3

Reference: HY-150567

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SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy....

(+)-Secoisolariciresinol

Reference: HY-N8172

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(+)-Secoisolariciresinol, a lignan compound, is a (+)-enantiomer of Secoisolariciresinol.

CCPA

Reference: HY-103185

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CCPA (2-Chloro-N6-cyclopentyladenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on...

3-Hydroxyoctanoic acid

Reference: HY-113058

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3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an...

1,3,5-Trimethoxybenzene

Reference: HY-Y0678

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1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor.

Anticancer agent 71

Reference: HY-147906

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Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and...

L-Valine-d8

Reference: HY-I1124

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L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino...

2’-O-(2-Azidoethyl)adenosine

Reference: HY-152870

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2’-O-(2-Azidoethyl)adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition...

TB-21007

Reference: HY-103510

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TB-21007 is an inverse agonist of α5β3γ2 subunit-containing GABAA receptor with a Ki of 1.6 nM. TB-21007 enhanced spatial memory in rats.

RBC10

Reference: HY-123464

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RBC10 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer...

Homosalate-d4

Reference: HY-B0928S

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Homosalate-d4 is the deuterium labeled Homosalate. Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage.

Mal-PEG12-NH-Boc

Reference: HY-138500

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Mal-PEG12-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fluorescein Biotin

Reference: HY-D1030

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Fluorescein Biotin is used as an alternative to radioactive biotin for detecting and quantitating biotin-binding sites by either fluorescence or absorbance; the the fluorescence or absorbance of Fluorescein Biotin is...

Enantiomer of Sofosbuvir

Reference: HY-I0726

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Enantiomer of Sofosbuvir is an enantiomer of Sofosbuvir, a prescription medicine for the treatment of patients with chronic hepatitis C. There is no biological activity report on enantiomer of Sofosbuvir until now.

Folate-PEG3-NHS ester

Reference: HY-133493

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Folate-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Pomalidomide-d4

Reference: HY-10984S2

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Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of...

Carbasalate calcium

Reference: HY-17476

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Carbasalate calcium is an anti-inflammatory, antipyretic, and analgesic agent.

Benzthiazide

Reference: HY-B1424

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Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also...

D-Glucose-13C-3

Reference: HY-B0389S13

€0.00 (tax incl.)

D-Glucose-13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism,...

Category: Reagents

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