Reagents (3)

Cadazolid

Reference: HY-100436

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Cadazolid (ACT-179811) is a new oxazolidinone antibiotic with potent activity against Clostridium difficile.

Naftopidil-d5 is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes,...

BI-4020

Reference: HY-129550

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BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines) but also the...

MRTX-1257

Reference: HY-114436

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MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.

Amlodipine

Reference: HY-B0317

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Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium....

THR-β agonist 3

Reference: HY-143614

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THR-β agonist 3 is a potent agonist of THR-β. THR-β agonist 3 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as...

(S)-2-acetamido-4-amino-4-oxobutanoic acid

Reference: HY-W016798

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(S)-2-acetamido-4-amino-4-oxobutanoic acid is an endogenous metabolite.

Lp-PLA2-IN-5

Reference: HY-142670

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Lp-PLA2-IN-5 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in...

SARS-CoV-2 nsp3-IN-1

Reference: HY-150062

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SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC50 value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1...

Vitamin B5-13C3,15N hemicalcium hemihydrate

Reference: HY-144432S

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Vitamin B5-13C3,15N (hemicalcium hemihydrate) is the deuterium labeled Vitamin B5 (hemicalcium hemihydrate)[1].

4-Hydroxybenzylamine

Reference: HY-W004078

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4-Hydroxybenzylamine is an endogenous metabolite.

COX-2-IN-28

Reference: HY-150553

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COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively.

Biotin-PEG2-acid

Reference: HY-126958

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Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Fmoc-NH-PEG9-CH2CH2COOH

Reference: HY-130167

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Fmoc-NH-PEG9-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG9-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

2',3',5'-Tri-O-acetyl-2-thiouridine

Reference: HY-154170

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2',3',5'-Tri-O-acetyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on...

Mal-Phe-C4-Val-Cit-PAB-DMEA

Reference: HY-126674

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Mal-Phe-C4-Val-Cit-PAB-DMEA is a cleavable ADC linker containing a Maleimide group. Mal-Phe-C4-Val-Cit-PAB-DMEA is used for making antibody-drug conjugate.

Sucistil

Reference: HY-145614

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Sucistil is an active compound. hemoglobin sucistil (bovine) is an oxygen carrier.

CDK7-IN-6

Reference: HY-145394

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CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC50≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5....

Amycolatopsin A

Reference: HY-N11048

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Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG)...

(-)-Corey lactone diol

Reference: HY-W008393

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(-)-Corey lactone diol is a reduced version of corey aldehyde. A building block in the chemical synthesis.

Dodecanoate-d2 potassium

Reference: HY-W115763S

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Dodecanoate-d2 (potassium) is the deuterium labeled Dodecanoate[1].

Dansylcadaverine

Reference: HY-D1027

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Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated...

Proglumide sodium

Reference: HY-103354

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Proglumide sodium is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide sodium selective blocks CCK’s effects in the central nervous system (CNS). Proglumide sodium has ability...

Antitubercular agent 34

Reference: HY-151957

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Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of MtbH37Rv with a MIC90 value of 1.25 μg/mL with the ability of escaping metabolic degradation by human...

RG3039

Reference: HY-102020

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RG3039 (PF-06687859) is an orally bioavailable and brain-penetrant DcpS inhibitor with an IC50 of 0.069 nM.

6-Methylnicotinamide

Reference: HY-W015815

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6-Methylnicotinamide, a derivate of nicotinamide, is an endogenous metabolite. A sudden increase of 6-methylnicotinamide in the acute stages of intracerebral hemorrhage (ICH) exacerbates neurological damages.

Ambroxide

Reference: HY-N1384

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Ambroxide is a naturally occurring terpenoid. Ambroxide is one of the key constituents of ambergris.

12:0 EPC chloride

Reference: HY-144017

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12:0 EPC chloride is a cationic phospholipid. 12:0 EPC chloride can be used for drug delivery.

ALV1

Reference: HY-145776

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ALV1 potently induces degradation of both Ikaros and Helios without unexpected off-target activity. ALV1 binds CRBN with IC50 of 0.55 µM. ALV1 degrades cells stably expressing IKZF1Δ and IKZF2Δ GFP fusions with...

Clevidipine-d7

Reference: HY-17436S1

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Clevidipine-d7 is the deuterium labeled Clevidipine. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative...

Ethyl undecanoate

Reference: HY-W014207

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Ethyl undecanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Butyl Palmitate

Reference: HY-W127338

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Butyl Palmitate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Temocaprilat

Reference: HY-A0117

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Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE). Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has...

Simvastatin acid calcium hydrate

Reference: HY-119695B

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Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human...

(Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5

Reference: HY-143699S

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(Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5 is the deuterium labeled (Rac)-1,2-Bis-palmitol-3-chloropropanediol[1].

6-Amino-5-azacytidine

Reference: HY-111643

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6-Amino-5-azacytidine inhibits the growth of bacteria E. coli.

FCCP

Reference: HY-100410

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FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.

Penicillin G-d7 potassium salt

Reference: HY-N7139S1

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Penicillin G-d7 (potassium) is the deuterium labeled Penicillin G potassium salt[1].

Casanthranol

Reference: HY-B2134

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Casanthranol is a concentrated mixture of anthranol glycosides from cascara sagrada (dried bark of Rhamnus p.) and used as a laxative in constipation and various medical conditions, stimulant laxative Casanthranol...

(±)-Hexanoylcarnitine chloride

Reference: HY-100978

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(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker...

Aficamten

Reference: HY-139465

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Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM).

Glycylglycine

Reference: HY-D0889

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Glycylglycine is the simplest of all peptides and could function as a gamma-glutamyl acceptor.

Mifepristone-13C,d3

Reference: HY-13683S1

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Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

AMG 579

Reference: HY-12913

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AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.

Imidacloprid-urea

Reference: HY-131964

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Imidacloprid-urea is a metabolite of Imidacloprid. Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Imidacloprid-urea can occupy or block...

(E)-4-Oxo-2-nonenal

Reference: HY-114524

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(E)-4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides....

EP4 receptor antagonist 1

Reference: HY-133123

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EP4 receptor antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist for cancer immunotherapy. EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM...

5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine

Reference: HY-154779

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5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this...

Methylkushenol C

Reference: HY-N10787

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Methylkushenol C is a phenolic substance. Methylkushenol C can be isolated from Sophora flavescens.

D-Glucose-d1-2

Reference: HY-B0389S4

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D-Glucose-d-22 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general...

1-O-Acetyl-6beta-O-Isobutyrylbritannilactone

Reference: HY-N10847

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1-O-Acetyl-6beta-O-Isobutyrylbritannilactone (compound 5), a sesquiterpene lactone, can be isolated from the flowers of Inula britannica. 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone shows significant cytotoxicity to...

PROTAC BRD4 Degrader-1

Reference: HY-133131

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PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression.

Notoginsenoside Fe

Reference: HY-N0046

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Notoginsenoside Fe is a natural compound isolated from Panax pseudo-ginseng.

Geraniol

Reference: HY-N6952

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Geraniol, an olefinic terpene, was found to inhibit growth of Candida albicans and Saccharomyces cerevisiae strains.

Xylose-3-13C

Reference: HY-N0537S5

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Xylose-3-13C is the 13C labeled Xylose.

Scopoletin acetate

Reference: HY-N1254

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Scopoletin acetate is a coumarin isolated from Artemisia granatensis.

Eravacycline

Reference: HY-16980

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Eravacycline is a potent and broad-spectrum antibacterial agent.

SD 0006

Reference: HY-11087

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SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α.

Fingolimod Mono-lactate-d4 hydrochloride

Reference: HY-143959S

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Fingolimod Mono-lactate-d4 (hydrochloride) is the deuterium labeled Fingolimod Mono-lactate hydrochloride[1].

GaTx2

Reference: HY-P1105

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GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in...

Estradiol-d3

Reference: HY-B0141S

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Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through...

Tortoside A

Reference: HY-N8154

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Tortoside A is a bioactive compound that could be found in the roots of Ilex pubescens.

Photosensitizer-2

Reference: HY-147690

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Photosensitizer-2 (compound 1) is a organic D-π-A sensitizer against phototoxicity. Photosensitizer-2 contains an acrylic acid moiety that exerts high levels of phototoxicity. Photosensitizer-2 shows antitumor...

Ezetimibe phenoxy glucuronide

Reference: HY-135391

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Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor.

Nabumetone

Reference: HY-B0559

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Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.

Vanillylmandelic acid-d1

Reference: HY-113121S1

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Vanillylmandelic acid-d is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the...

(Asp37)-Amyloid β-Protein (1-42)

Reference: HY-P4391

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(Asp37)-Amyloid β-Protein (1-42) is the G37D mutant of wild-type Amyloid-beta (1-42) peptide.

LY 254155

Reference: HY-14523

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LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.

CAPS

Reference: HY-D0869

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CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis.

L-Leucine-d1

Reference: HY-N0486S11

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L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

D-Allose

Reference: HY-128741

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D-Allose is an endogenous metabolite.

14-Deoxy-11,12-didehydroandrographolide

Reference: HY-N1490

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14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation.

Carboxy primaquine-d4

Reference: HY-142842S

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Carboxy primaquine-d4 is the deuterium labeled Carboxy primaquine[1].

FASN-IN-4 tosylate

Reference: HY-12648A

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FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM.

LpxH-IN-AZ1

Reference: HY-130836

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LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .

m-PEG12-acid

Reference: HY-135820

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m-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Griseoluteic acid

Reference: HY-118651

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Griseoluteic acid, a phenazine antibiotic, is originally isolated from S. griseoluteus. Griseoluteic acid is a breakdown product of griseolutein A and B.

APJ receptor agonist 3

Reference: HY-139876

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APJ receptor agonist 3 is a potent and orally active APJ receptor agonist with an EC50 value of 0.027 nM.

Cyclopropyl-1 Methyl-Ketone-d4

Reference: HY-Y0226S

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Cyclopropyl-1 Methyl-Ketone-d4 is the deuterium labeled Cyclopropyl methyl ketone[1].

Cholesteryl palmitate-d9

Reference: HY-W010708S

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Cholesteryl palmitate-d9 is the deuterium labeled Cholesteryl palmitate. Cholesteryl palmitate is a useful prognostic biomarker for chronic interstitial pneumonia (CIP).

endo-BCN-PEG2-NH2

Reference: HY-W072752

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endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

diABZI STING agonist-1 (Tautomerism)

Reference: HY-112921

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diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

HBV-IN-17

Reference: HY-144320

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HBV-IN-17 (compound 8) is a potent HBV capsid assembly modulator with an EC50 of 511 nM.

A2ti-2

Reference: HY-136466

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A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2...

Antibacterial agent 87

Reference: HY-146591

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Antibacterial agent 87 (Compound 4h) is a potent antibacterial agent with MIC values of 0.125, 0.0625 and 0.0625 μg/mL against MRSA, MRSE and S. aureus, respectively.

Balsalazide-d4

Reference: HY-B0667S1

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Balsalazide-d4 is deuterium labeled Balsalazide. Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

Nebentan

Reference: HY-106994

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Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to...

Bis-aminooxy-PEG2

Reference: HY-140408

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Bis-aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

(S,R,S)-AHPC-Me-C10-Br

Reference: HY-130642

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(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901.

Pyrithioxin

Reference: HY-B0910

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Pyrithioxin is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia.

Alpinetin

Reference: HY-N0625A

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Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.

L-Leucyl-L-alanine

Reference: HY-128434

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L-Leucyl-L-alanine is a simple dipeptide composed of L-leucine and L-alanine.

VB124

Reference: HY-139665

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VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC50s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is...

NH2-PEG5-C1-Boc

Reference: HY-135938

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NH2-PEG5-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-N-amido-PEG6-amine

Reference: HY-138331

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Fmoc-N-amido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Taurochenodeoxycholic acid-d4-1 sodium

Reference: HY-N1429S2

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Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid....

Ethyl linoleate-d2

Reference: HY-W013812S2

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Ethyl linoleate-d2 (Linoleic Acid ethyl ester-d2; Mandenol-d2) is the deuterium labeled Ethyl linoleate (HY-W013812). Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and...

Midafotel

Reference: HY-107718

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Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects.