Reagents (2)

GSK461364

Reference: HY-50877

€0.00 (tax incl.)

GSK461364 is a selective, reversible and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with a Ki value of 2.2 nM.

DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or...

Tebipenem pivoxil

Reference: HY-B0396

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Tebipenem pivoxil (L084) is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis.

1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one

Reference: HY-N10158

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1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (compound 39), a diarylheptanoid, exhibits antiproliferative activity towards human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells.

ZL-Pin13

Reference: HY-143903

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ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the...

Clomipramine-13C,d3 hydrochloride

Reference: HY-B0457S2

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Clomipramine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM....

α,β-Trehalose

Reference: HY-W145656

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α,β-Trehalose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

14-Demethyl-lanosterol-d6

Reference: HY-146777S

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14-Demethyl-lanosterol-d6 is deuterium labeled 14-Demethyl-lanosterol.

Lenalidomide-C5-NH2 hydrochloride

Reference: HY-122725B

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Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as...

Eldecalcitol-d6

Reference: HY-A0020S

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Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis.

Acetic acid magnesium tetrahydrate

Reference: HY-Y0319G

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Acetic acid magnesium tetrahydrate is a hydrated form of anhydrous magnesium acetate salt. As a salt form of Magnesium, Magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble...

Coenzyme Q10-d9

Reference: HY-N0111S2

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Coenzyme Q10-d9 is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

Britannilactone diacetate

Reference: HY-N4190

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Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial...

EB-0156

Reference: HY-145274

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EB-0156 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC50s of 0.0479 and less than 0.001 μM, respectively. EB-0156 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0156...

Doxorubicin-13C,d3 TFA

Reference: HY-15142AS1

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Doxorubicin-13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicin. Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase...

Hydroxy naphthol blue disodium

Reference: HY-W151206

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Hydroxy naphthol blue disodium, an azo dye, is a metal indicator for calcium and a colorimetric reagent for alkaline earth metal ions ( λmax = 650 nm). In the pH range between 12 and 13, the solution of the indicator...

HS56

Reference: HY-123983

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HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction....

Acoramidis hydrochloride

Reference: HY-109165A

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Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis.

(S)-GNE-140

Reference: HY-100742B

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(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

SC 34301

Reference: HY-105052

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SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice.

(S)-(-)-Bay-K-8644

Reference: HY-15124

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(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).

CC-17369

Reference: HY-123215

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CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for...

D-Glucose-13C-4

Reference: HY-B0389S16

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D-Glucose-13C-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism,...

Antitubercular agent-10

Reference: HY-132928

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Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.

Imiclopazine

Reference: HY-137088

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Imiclopazine is a phenothiazine derivative with with psychomotor stabilizing properties, antiaggressive and antiemetic effects.

11,12-De(methylenedioxy)danuphylline

Reference: HY-N1013

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11,12-De(methylenedioxy)danuphylline is an indole alkaloid compound isolated from the leaves and stems of Kopsia officinalis.

Methyl propionate-PEG12

Reference: HY-130186

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Methyl propionate-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

DRB18

Reference: HY-145963

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DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and...

SJM-3

Reference: HY-131941

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SJM-3 is a positive allosteric modulator of different isoforms of the GABAA receptor. SJM-3 binds at the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.

LC kinetic stabilizer-2

Reference: HY-145890

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LC kinetic stabilizer-2 is a potent amyloidogenic immunoglobulin light chain (LC) kinetic stabilizer with an EC50 of 24 nM.

SARS-CoV-2-IN-23 disodium

Reference: HY-151269A

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SARS-CoV-2-IN-23 disodium is a two-armed diphosphate ester and medium length molecular tweezers. SARS-CoV-2-IN-23 disodium exhibits antiviral activity with IC50s of 8.2 μM and 2.6 μM against SARS-CoV-2 activity and...

Sodium dodecyl sulfate for molecular biology

Reference: HY-Y0316C

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Sodium dodecyl sulfate,for molecular biology,≥98.5% is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Methotrexate α-tert-butyl ester

Reference: HY-133887

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Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and...

5-Oxoprolyltryptophan

Reference: HY-118570

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5-Oxoprolyltryptophan is a model substrate for investigating the increase of serotonin at the cerebral level.

Belinostat

Reference: HY-10225

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Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.

Enniatin complex

Reference: HY-N6706

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Enniatin complex is a mixture of cyclohexadepsipeptides isolated largely from Fusarium species of fungi, and has ionophoric, antibiotic, and in vitro hypolipidaemic properties. Enniatin complex inhibits enzymes like...

Brilliant blue G-250

Reference: HY-D0014

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Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation. In the Bradford protein assay, protein concentrations...

20S Proteasome-IN-2

Reference: HY-150590

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20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC50 of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in...

2-Azidoethyl β-D-glucopyranoside

Reference: HY-W145563

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2-Azidoethyl β-D-Glucopyranoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

INCB38579

Reference: HY-101188

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INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and...

SMO-IN-3

Reference: HY-150567

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SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy....

(+)-Secoisolariciresinol

Reference: HY-N8172

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(+)-Secoisolariciresinol, a lignan compound, is a (+)-enantiomer of Secoisolariciresinol.

CCPA

Reference: HY-103185

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CCPA (2-Chloro-N6-cyclopentyladenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on...

3-Hydroxyoctanoic acid

Reference: HY-113058

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3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an...

1,3,5-Trimethoxybenzene

Reference: HY-Y0678

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1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor.

Anticancer agent 71

Reference: HY-147906

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Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and...

L-Valine-d8

Reference: HY-I1124

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L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino...

2’-O-(2-Azidoethyl)adenosine

Reference: HY-152870

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2’-O-(2-Azidoethyl)adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition...

TB-21007

Reference: HY-103510

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TB-21007 is an inverse agonist of α5β3γ2 subunit-containing GABAA receptor with a Ki of 1.6 nM. TB-21007 enhanced spatial memory in rats.

RBC10

Reference: HY-123464

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RBC10 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer...

Homosalate-d4

Reference: HY-B0928S

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Homosalate-d4 is the deuterium labeled Homosalate. Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage.

Mal-PEG12-NH-Boc

Reference: HY-138500

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Mal-PEG12-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fluorescein Biotin

Reference: HY-D1030

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Fluorescein Biotin is used as an alternative to radioactive biotin for detecting and quantitating biotin-binding sites by either fluorescence or absorbance; the the fluorescence or absorbance of Fluorescein Biotin is...

Enantiomer of Sofosbuvir

Reference: HY-I0726

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Enantiomer of Sofosbuvir is an enantiomer of Sofosbuvir, a prescription medicine for the treatment of patients with chronic hepatitis C. There is no biological activity report on enantiomer of Sofosbuvir until now.

Folate-PEG3-NHS ester

Reference: HY-133493

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Folate-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Pomalidomide-d4

Reference: HY-10984S2

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Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of...

Carbasalate calcium

Reference: HY-17476

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Carbasalate calcium is an anti-inflammatory, antipyretic, and analgesic agent.

Benzthiazide

Reference: HY-B1424

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Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also...

D-Glucose-13C-3

Reference: HY-B0389S13

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D-Glucose-13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism,...

Acetylspiramycin

Reference: HY-B1916

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Acetylspiramycin (Spiramycin B; Spiramycin II; Foromacidin B) is a potent and orally active macrolide antibiotic produced by various Streptomyces species, an acetylated derivative of Spiramycin (HY-100593)....

Alisol A

Reference: HY-N0853

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Alisol A is a natural product.

AM-2099

Reference: HY-100727

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AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16 μM for human Nav1.7.

TREM2 agonist-2

Reference: HY-148095

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TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50

Eurycomalactone

Reference: HY-N4327

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Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and...

Fmoc-N-Me-Ala-OH

Reference: HY-W008235

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Fmoc-N-Me-Ala-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction.

Casopitant mesylate

Reference: HY-14405A

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Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the...

PTP1B-IN-17

Reference: HY-144718

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PTP1B-IN-17 (Compound 45), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 30.2 μM. PTP1B-IN-17 can be used for the research of type 2 diabetes.

GSK343

Reference: HY-13500

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GSK343 is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.

iMAC2

Reference: HY-103272

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iMAC2 is a potent MAC inhibitor with an IC50 of 28 nM and an LD50 of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release.

Cholic acid sodium hydrate

Reference: HY-N0324B

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Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic...

Chitin synthase inhibitor 10

Reference: HY-151420

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Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an...

YKL-5-124 TFA

Reference: HY-101257B

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YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than...

Nrf2 activator-7

Reference: HY-149244

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Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway in NCM460D cells.

endo-BCN-PEG4-Val-Cit-PAB-MMAE

Reference: HY-141155

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endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol

Reference: HY-131897S

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1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids....

BDP TR methyltetrazine

Reference: HY-D1646

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BDP TR methyltetrazine is a BDP dye linker containing a methyltetrazine group.

(S)-(-)-5-Fluorowillardiine hydrochloride

Reference: HY-16713A

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(S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.

(Phe13,Tyr19)-MCH (human, mouse, rat)

Reference: HY-P4680

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(Phe13,Tyr19)-MCH (human, mouse, rat) is a potent SLC-1 and S643b receptor ligand. (Phe13,Tyr19)-MCH (human, mouse, rat) can be used as an agonist for SLC-1 and S643b receptor.

Fluorescein-5-thiosemicarbazide

Reference: HY-D0099

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Fluorescein-5-thiosemicarbazide is a amine containing fluorescent probe that can be used for labeling saccharides and protein carbonyl derivatives.

Trofosfamide

Reference: HY-119824

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Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity.

Palbociclib-propargyl

Reference: HY-130296

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Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6.

7-Iodo-2',3'-dideoxy-7-deaza-guanosine

Reference: HY-W048479

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7-Iodo-2',3'-dideoxy-7-deaza-guanosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions.

Mirdametinib

Reference: HY-10254

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Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC50 of 0.33 nM. Mirdametinib exhibits a Kiapp of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the...

Probenecid

Reference: HY-B0545

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Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.

Azido-PEG16-Boc

Reference: HY-140784

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Azido-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

KRAS G12C inhibitor 29

Reference: HY-142478

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KRAS G12C inhibitor 29 is a KRAS G12C inhibitor extracted from patent WO2021252339A1, compound 3. KRAS G12C inhibitor 29 can be used for the research of cancer.

p-Toluic acid-d4

Reference: HY-76547S

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p-Toluic acid-d4 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted?benzoic acid?and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid...

4′,5′-Didehydro-5′-deoxyadenosine

Reference: HY-154232

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4′,5′-Didehydro-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on...

(±)-β-Methylphenethylamine-d9

Reference: HY-W213592S

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(±)-β-Methylphenethylamine-d9 is the deuterium labeled (±)-β-Methylphenethylamine[1].

Niraparib tosylate hydrate

Reference: HY-10619E

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Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA...

Cjoc42

Reference: HY-138054

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Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin....

Ekersenin

Reference: HY-N11509

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Ekersenin is a natural product that can be isolated from Ekererbegia senegalensis.

Doxycycline (hyclate)

Reference: HY-N0565B

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Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity.

Ergothioneine

Reference: HY-N1914

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Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant.

20-Deoxocarnosol

Reference: HY-122944

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20-Deoxocarnosol (compound 7) is a potent anti-cancer agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells.

TC-E 5008

Reference: HY-110144

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TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E...