Aprotinin Reference: 073-70 800277 Aprotinin is a polypeptide extracted from bovine lung and composed of 58 amino acids with a molecular weight of 6’512 Daltons. Aprotinin is a polyvalent reversible inhibitor of serine proteinases including plasmin and kallikrein. The active loop contains the reactive lysine residue in position 15, the tertiary structure shows a pear-shaped unit which fits exactly into the binding site of serine proteinases. Aprotinin slows down fibrinolysis, the process that leads to the breakdown of blood clots. In addition to its anti-fibrinolytic activity, aprotinin is also thought to preserve platelet function and have anti-inflammatory effects, both of which may be mediated by inhibition of protease-activated receptors expressed on platelets, vascular endothelium, and neutrophils.
Pefabloc® SC Reference: 399-01 C8H10FNO2S · HCl Pefabloc® SC is an irreversible proteinase inhibitor with broad specificity for serine proteinases.
Pefabloc® FG Reference: 099-01 H-Gly-Pro-Arg-Pro-OH · AcOH Pefabloc® FG binds with a high affinity to fibrinogen, inhibits fibrin polymerization, modifies the mechanical properties of fibrin clots and can dissociate non-stabilized fibrin gels.
Pefabloc® TH (α-NAPAP) Reference: 381-01 C27H31O4N5S · AcOH Nα-(2-Naphthylsulfonylglycyl)-4-amidino-(D,L)-phenylalanine piperidide · AcOH Pefabloc® TH (NAPAP) is one of the most potent and selective competitive inhibitors of thrombin.
r-hirudin EC Reference: 126-10 Hirudin is the most potent and specific thrombin inhibitor known. It forms a stable equimolar complex with thrombin. The complete structure of hirudin has been elucidated [Dodt et al., 1984] and a gene coding for hirudin was subsequently synthesized and expressed in yeast [Meyhack et al., 1987] and other micro-organisms. The amino acid sequence of recombinant hirudin (r-Hirudin, [Leu1, Thr2]-63-desulfatohirudin) corresponds to natural hirudin except for the substitution of leucine for isoleucine at the Nterminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.