Mouse PTHrP protein, His tag Reference: GTX00047-pro This gene encodes a member of the parathyroid family of hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 215]
Mouse Fibrillin 1 protein, His tag Reference: GTX00048-pro This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Homozygous knockout mice for this gene exhibit impaired aortic development and early postnatal death, which was attributed to a deficiency in the fibrillin-1 protein. Mice with a hypomorphic allele of this gene exhibit impaired glucose homeostasis, likely due to a reduction in serum asprosin levels. [provided by RefSeq, Apr 216]
Mouse IGF1 protein, His tag (active) Reference: GTX00049-pro This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 215]
Rat IL1 Receptor 1 protein, His tag Reference: GTX00051-pro receptor for interleukin-1; involved in inflammatory response signalling [RGD, Feb 26]
Rat IL1 Receptor 1 protein, His tag Reference: GTX00052-pro receptor for interleukin-1; involved in inflammatory response signalling [RGD, Feb 26]
Rat IL1 Receptor 1 protein, His tag Reference: GTX00053-pro receptor for interleukin-1; involved in inflammatory response signalling [RGD, Feb 26]
Rat Coagulation factor III/Tissue Factor protein, His tag Reference: GTX00054-pro an initiation factor for blood coagulation; plays a critical role in hepatic ischemic reperfusion injury [RGD, Feb 26]
Rat Noggin protein, His and MBP tag Reference: GTX00055-pro secreted protein; involved in dorsal fate specification [RGD, Feb 26]
Rat Noggin protein, His and GST tag Reference: GTX00056-pro secreted protein; involved in dorsal fate specification [RGD, Feb 26]
Rat Coagulation Factor II protein, His tag Reference: GTX00058-pro catalyzes the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptides A and B; involved in blood coagulation and wound repair [RGD, Feb 26]