Category: Proteins & Peptides

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Reference: P7091

Synonyms: IkB kinase associated protein 1, IkB kinase subunit gamma, Inhibitor of nuclear factor kappa B kinase subunit gamma, AMCBX1, FIP 3, FIP-3, FIP3, Fip3p, I kappa B kinase gamma, I-kappa-B kinase subunit gamma, IkB kinase gamma subunit, IkB kinase subunit gamma, IkB kinase-associated protein 1, Ikbkg, IKK gamma, IKK-gamma, IKKAP1, IKKG, IMD33, Incontinentia pigmenti. Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4

Reference: P7092

Synonyms: IkB kinase associated protein 1, IkB kinase subunit gamma, Inhibitor of nuclear factor kappa B kinase subunit gamma, AMCBX1, FIP 3, FIP-3, FIP3, Fip3p, I kappa B kinase gamma, I-kappa-B kinase subunit gamma, IkB kinase gamma subunit, IkB kinase subunit gamma, IkB kinase-associated protein 1, Ikbkg, IKK gamma, IKK-gamma, IKKAP1, IKKG, IMD33, Incontinentia pigmenti. Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4

Reference: P7093

Synonyms: Hepatocellular carcinoma autoantigen p62, IF2B2_HUMAN, IGF 2 mRNA binding protein 2, IGF II mRNA binding protein 2, IGF-II mRNA-binding protein 2, IGF2 mRNA-binding protein 2, Igf2bp2, IMP 2, IMP-2, IMP2, Insulin like growth factor 2 mRNA binding protein 2, Insulin-like growth factor 2 mRNA-binding protein 2, OTTHUMP00000082606, OTTHUMP00000082607, OTTHUMP00000082608, p62, VICKZ 2, VICKZ family member 2. Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4

Reference: P7094

Synonyms: CD 265, CD265, FEO, LOH18CR1, Loss of heterozygosity 18 chromosomal region 1, mRANK, ODFR, OFE, OPTB7, Osteoclast differentiation factor receptor, OSTS, Paget disease of bone 2, PDB 2, PDB2, RANK, Receptor activator of NF KB, Receptor activator of NF-KB, receptor activator of nuclear factor kappa B, TNF receptor superfamily member 11a, TNFRSF11A, TNR11_HUMAN, TRANCER. Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4

Reference: P7095

Synonyms: Ccl8, CCL8_HUMAN, HC14, MCP-2, MCP-2(6-76), Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, SCYA10, SCYA8, Small-inducible cytokine A8. Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4

Reference: P7096

Synonyms: C-X-C motif chemokine 4, Chemokine (C X C motif) ligand 4, Chemokine (CXC motif) ligand 4, chemokine ligand 4, CXCL 4, CXCL4, Iroplact, MGC138298, Oncostatin A, Oncostatin-A, OncostatinA, PF 4, PF-4, PF4, Pf4a, Platelet factor 4, PLF4_HUMAN, SCYB 4, SCYB4, short form, Small inducible cytokine subfamily B, Small inducible cytokine subfamily member 4. Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4

Reference: P7097

Synonyms: ALP, C-C motif chemokine 27, CC chemokine ILC, Ccl27, CCL27_HUMAN, Chemokine (C-C motif) ligand 27, CTACK, CTAK, Cutaneous T cell attracting chemokine, Cutaneous T-cell-attracting chemokine, ESkine, IL 11 R alpha locus chemokine, IL-11 R-alpha-locus chemokine, ILC, PESKY, SCYA27, Skinkine, Small inducible cytokine A27, small inducible cytokine subfamily A (Cys-Cys), member 27, Small-inducible cytokine A27. Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4

Reference: R00121

Fibroblast Growth Factor basic (FGF-basic/FGF-2) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FGF-1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Other homologous FGF belonging to the same family are int-2 (FGF-3), FGF-5, FGF-6, K-FGF and KGF ( keratinocyte growth factor = FGF-7). All factors are products of different genes, some of which are Oncogene products ( FGF-3, FGF-4, FGF-5 ).

Reference: R00121-1

Fibroblast Growth Factor basic (FGF-basic/FGF-2) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FGF-1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Other homologous FGF belonging to the same family are int-2 (FGF-3), FGF-5, FGF-6, K-FGF and KGF (keratinocyte growth factor = FGF-7). All factors are products of different genes, some of which are Oncogene products (FGF-3, FGF-4, FGF-5).

Reference: R00804

Oncostatin-M (OSM) is amember of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophagecolony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Reference: R00609

Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons. Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE.

Reference: R01931-1

KGF (keratinocyte growth factor), also known as FGF-7 (fibroblast growth factor-7), is one of 22 known members. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.