Rat Caspase 1 protein, His tag Reference: GTX00060-pro apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD, Feb 26]
Rat SLIT2 protein, His tag Reference: GTX00062-pro acts as a ligand for glypican-1, a heparan sulfate proteoglycan; may play a role in neurogenesis and midline development [RGD, Feb 26]
Rat TIMP3 protein, His tag Reference: GTX00064-pro may inhibit metalloendopeptidase activity; may play a role in induction of apoptosis [RGD, Feb 26]
Rat SFRP1 protein, His tag (active) Reference: GTX00065-pro a secreted protein involved in binding Wnt and antagonizing Wnt signaling [RGD, Feb 26]
Rat GADD45A protein, His tag Reference: GTX00066-pro may mediate a delay in G2 to M cell cycle progression; may induce DNA repair [RGD, Feb 26]
Human IL1 alpha protein, His tag (active) Reference: GTX00067-pro The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimers disease. [provided by RefSeq, Jul 28]
Human TRAIL protein, His tag Reference: GTX00068-pro The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF1A/TRAILR1, TNFRSF1B/TRAILR2, TNFRSF1C/TRAILR3, TNFRSF1D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF1C/TRAILR3, TNFRSF1D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 21]
Human Prolactin protein, His tag (active) Reference: GTX00069-pro This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 211]