anti-Prolactin antibody [PRL-1]

Prolactin (PRL) is primarily secreted by pituitary gland. The hormone stimulates mammary gland development during pregnancy and lactation after childbirth. PRL has several variations with molecular weights ranged from 22kDa to 150kDa. PRL receptors are mainly located at mammary glands, and also found in other organs and tissues. PRL can bind to cytokine-like receptors and influence haematopoiesis, angiogenesis, and immuno-system. Anterior pituitary tumours can cause persistent elevation of PRL with clinical signs such as abnormal lactation, infertility and lack of menstrual flow in women, and incompetence in men.