BRD2 bromodomain 1 (human, recombinant) Reference: 11071-100 Source: Recombinant N-terminal GST-tagged protein expressed in E. coli • MW: 42.4 kDa
Rheb blocking peptide Reference: GTX31713-PEP This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 1 and one on chromosome 22. [provided by RefSeq, Jul 28]
Histone H2A Type 1 (human, recombinant) Reference: 11080-500 Source: Recombinant human histone H2A type 1 expressed in E. coli • Amino acids: 2-130 (full length) • MW: 13.96 kDa
4E-BP1 blocking peptide Reference: GTX31714-PEP This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 4S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 28]
Histone H2B Type 1-A (human, recombinant) Reference: 11081-500 Source: Recombinant human histone H2B type 1-A expressed in E. coli • Amino acids: 2-127 (full length) • MW: 14.04 kDa
IRS1 blocking peptide Reference: GTX31717-PEP This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 29]
O6-methylguanine-DNA Methyltransferase (human recombinant) Reference: 11176-100 Active recombinant N-terminal His-tagged protein expressed in E. coli • O6-methylguanine-DNA Methyltransferase (MGMT) is a DNA repair enzyme responsible for demethylating O6-methylguanine (O6-mG).
Adiponectin blocking peptide Reference: GTX31718-PEP This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 21]
DPY-30 (human recombinant) Reference: 11178-50 Recombinant protein expressed in E. coli • DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L.
Adiponectin blocking peptide Reference: GTX31719-PEP This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 21]
Vimentin (human recombinant) Reference: 11234-100 Source: Recombinant N-terminal histidine-tagged vimentin purified from E. coli • MW: 55.2 kDa,
Beclin 1 blocking peptide Reference: GTX31721-PEP Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 29 [PubMed 1927693]).[supplied by OMIM, Jul 21]