TAT-P4-(DATC5)2 Reference: HY-P2298 TAT-P4-(DATC5)2 is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 can inhibit addiction in rats.
Spadin Reference: HY-P1422 Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC50 value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research.
GsMTx4 Reference: HY-P1410 GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
EGF Receptor Substrate 2 (Phospho-Tyr5) Reference: HY-P0320 EGF Receptor Substrate 2 (Phospho-Tyr5) is a biologically active peptide derived from an autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR).
3-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid Reference: HY-W067091 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid is an alanine derivative.